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©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Nov 21, 2019; 25(43): 6404-6415
Published online Nov 21, 2019. doi: 10.3748/wjg.v25.i43.6404
Published online Nov 21, 2019. doi: 10.3748/wjg.v25.i43.6404
Mitochondrial metabolomic profiling for elucidating the alleviating potential of Polygonatum kingianum against high-fat diet-induced nonalcoholic fatty liver disease
Xing-Xin Yang, Jia-Di Wei, Jian-Kang Mu, Feng-Jiao Li, Yan-Qin Li, Wen Gu, Jing-Ping Li, Jie Yu, College of Pharmaceutical Science, Yunnan University of Chinese Medicine, Kunming 650500, Yunnan Province, China
Xin Liu, Beijing Entry-Exit Inspection and Quarantine Bureau, Beijing 100026, China
Author contributions: Yang XX and Mu JK wrote the manuscript; Wei JD, Yang XX, and Li FJ performed the experiments; Liu X provided technical support and suggestions; Mu JK, Li YQ, Gu W, and Li JP participated in writing and modifying the manuscript; Yang XX and Yu J designed the study; The final manuscript has been approved by all the co-authors; Yang XX, Wei JD and Mu JK contributed equally to this work.
Supported by the National Natural Science Foundation of China , No. 81660596 ; the National Natural Science Foundation of China , No. 81760733 ; the Application and Basis Research Project of Yunnan , China, No. 2017FF117-013 ; the Application and Basis Research Project of Yunnan , China, No. 201801CH00227 ; and the Application and Basis Research Project of Yunnan , China, No. 2016FD050 .
Institutional review board statement: This study was reviewed and approved by the Institutional Ethical Committee on Animal Care and Experimentations of Yunnan University of Chinese Medicine.
Institutional animal care and use committee statement: Approval from the Institutional Ethical Committee on Animal Care and Experimentations of Yunnan University of Chinese Medicine was obtained for this study.
Conflict-of-interest statement: The authors declare no conflict of interest associated with this manuscript.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Jie Yu, PhD, Professor, College of Pharmaceutical Science, Yunnan University of Chinese Medicine, 1076 Yuhua Road, Kunming 650500, Yunnan Province, China. cz.yujie@gmail.com
Telephone: +86-871-65933303 Fax: +86-871-65933303
Received: September 2, 2019
Peer-review started: September 2, 2019
First decision: September 19, 2019
Revised: October 15, 2019
Accepted: October 30, 2019
Article in press: October 30, 2019
Published online: November 21, 2019
Peer-review started: September 2, 2019
First decision: September 19, 2019
Revised: October 15, 2019
Accepted: October 30, 2019
Article in press: October 30, 2019
Published online: November 21, 2019
Core Tip
Core tip: We identified the molecular mechanism behind the mitochondrial regulatory action of Polygonatum kingianum against high-fat diet (HFD)-induced non-alcoholic fatty liver disease (NAFLD) in rats using an integrated mitochondrial metabolomic method. The results indicated that Polygonatum kingianum can alleviate HFD-induced NAFLD by regulating riboflavin metabolism, increasing flavin mononucleotide content and further improving mitochondrial functions. Polygonatum kingianum as a promising mitochondrial regulator/nutrient can alleviate NAFLD-associated diseases.