Published online Nov 14, 2019. doi: 10.3748/wjg.v25.i42.6299
Peer-review started: July 22, 2019
First decision: August 27, 2019
Revised: September 27, 2019
Accepted: November 1, 2019
Article in press: November 1, 2019
Published online: November 14, 2019
Core tip: Studies have shown that long non-coding RNAs (lncRNAs) play a key role in almost all key physiological and pathological processes, including different types of malignant tumors. Our previous lncRNA microarray results have shown that lncRNA XLOC_001659 is upregulated in esophageal squamous cell carcinoma (ESCC) tissues, with a fold change of 20.9 relative to normal esophageal tissues. But its effect and the molecular biological mechanisms on proliferation and invasion of ESCC cells remain unclear. Here we showed that knockdown of lncRNA XLOC_001659 inhibited proliferation and invasion of ESCC cells via regulation of miR-490-5p/PIK3CA, suggesting that it may play a role in ESCC tumorigenesis and progression.