Basic Study
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Nov 7, 2019; 25(41): 6222-6237
Published online Nov 7, 2019. doi: 10.3748/wjg.v25.i41.6222
MiR-32-5p aggravates intestinal epithelial cell injury in pediatric enteritis induced by Helicobacter pylori
Jing Feng, Jian Guo, Jun-Ping Wang, Bao-Feng Chai
Jing Feng, Bao-Feng Chai, Institute of Loess Plateau, Shanxi University, Taiyuan 030006, Shanxi Province, China
Jing Feng, Jun-Ping Wang, Department of Gastroenterology, Shanxi Provincial People's Hospital, The Affiliated People's Hospital of Shanxi Medical University, Taiyuan 030012, Shanxi Province, China
Jian Guo, Department of General Surgery, Shanxi Provincial People's Hospital, The Affiliated People's Hospital of Shanxi Medical University, Taiyuan 030012, Shanxi Province, China
Author contributions: Chai BF and Wang JP designed the research; Feng J and Guo J performed the research; Feng J and Chai BF analyzed the data; Feng J and Wang JP wrote the paper.
Institutional review board statement: The study was reviewed and approved by the Ethics Committee of Shanxi University and Ethics Committee of Shanxi Provincial People's Hospital, Shanxi Province, China.
Conflict-of-interest statement: There was no competing interest.
Data sharing statement: All the data in the current research are available from the corresponding author on reasonable request.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Bao-Feng Chai, MD, PhD, Professor, Institute of Loess Plateau, Shanxi University, No. 92, Wucheng Road, Taiyuan 030006, Shanxi Province, China.
Telephone: +86-13603583312
Received: January 26, 2019
Peer-review started: August 27, 2019
First decision: September 19, 2019
Revised: October 11, 2019
Accepted: October 22, 2019
Article in press: October 22, 2019
Published online: November 7, 2019
Core Tip

Core tip: Our study demonstrated the harmful role of aberrant miR-32-5p in Helicobacter pylori (H. pylori)-infected intestinal epithelial cells. Further investigation showed that SMAD family member 6 (SMAD6) was the downstream of miR-32-5p and exerted an opposite role in this process. What’s more, miR-32-5p/SMAD6 contributed to transforming growth factor-β-activated kinase 1-p38 cascade activation in intestinal epithelial cells under H. pylori infection. These findings provide a novel insight into the pathogenesis of pediatric enteritis caused by H. pylori.