Giovanni Dothel, Maria Rosaria Spirito, Fabrizio De Ponti, Department of Medical and Surgical Sciences, University of Bologna, Bologna 40126, Italy
Chiara Bernardini, Augusta Zannoni, Roberta Salaroli, Maria Laura Bacci, Monica Forni, Department of Veterinary Medical Sciences, University of Bologna, Bologna 40064, Italy
Author contributions: Dothel G, Zannoni A, Bernardini C and Forni M conceived and designed the study; Dothel G, Salaroli R and Spirito MR performed the experiments; Dothel G, Bernardini C and Forni M wrote the paper; Dothel G performed the data analysis; Bacci ML carried out the procedures on pigs; De Ponti F and Forni M coordinated the research; all authors reviewed and participated to the paper drafting.
Supported by Fondazione del Monte di Bologna e Ravenna (ID ROL: FdM/3208).
Institutional review board statement: This study was approved by the institutional review board of National Institute of Health.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of the University of Bologna (approved experimental protocol for the use of guinea pigs: protocol number - 18/79/14; approved experimental protocol for the use of pigs: protocol number - 43-IX/9 all.37; 15/04/2013).
Conflict-of-interest statement: None of the authors have any potential conflicts of interest associated with this research.
ARRIVE guidelines statement: The present study was conceived, designed and performed following the ARRIVE guidelines. All the authors have read the ARRIVE guidelines and reviewed the manuscript accordingly.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Monica Forni, PhD, Associate Professor, Department of Veterinary Medical Sciences, University of Bologna, Via Tolara di Sopra 50, Ozzano dell'Emilia, Bologna 40064, Italy. firstname.lastname@example.org
Telephone: +39-51-2097913 Fax: +39-51-2097899
Received: April 11, 2019
Peer-review started: April 11, 2019
First decision: May 17, 2019
Revised: May 31, 2019
Accepted: June 8, 2019
Article in press: June 8, 2019
Published online: September 7, 2019