Published online Sep 7, 2019. doi: 10.3748/wjg.v25.i33.4885
Peer-review started: March 26, 2019
First decision: May 30, 2019
Revised: June 10, 2019
Accepted: June 25, 2019
Article in press: June 26, 2019
Published online: September 7, 2019
Core tip: Occupational exposure to vinyl chloride monomer (VCM) causes chronic liver disease, liver angiosarcoma, and hepatocellular carcinoma. VCM exposure has a synergistic effect with other known risk factors of liver diseases such as alcohol consumption and chronic viral infection. Further research is warranted to assess the risk of liver cancer at low levels of exposure and to investigate the patterns of risk with time since exposure.