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©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 7, 2019; 25(33): 4870-4884
Published online Sep 7, 2019. doi: 10.3748/wjg.v25.i33.4870
Published online Sep 7, 2019. doi: 10.3748/wjg.v25.i33.4870
Helicobacter pylori virulence genes
Anja Šterbenc, Erika Jarc, Mario Poljak, Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Ljubljana 1000, Slovenia
Matjaž Homan, Department of Gastroenterology, Hepatology and Nutrition, University Children’s Hospital, Faculty of Medicine, University of Ljubljana, Ljubljana 1000, Slovenia
Author contributions: All authors contributed equally to this paper, with conception and design of the study, literature review and analysis, drafting and critical revision and editing, and final approval of the final version.
Conflict-of-interest statement: No potential conflicts of interest. No financial support.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Matjaž Homan, MD, PhD, Assistant Professor, Department of Gastroenterology, Hepatology and Nutrition, University Children’s Hospital, Faculty of Medicine, University of Ljubljana, Bohoričeva 20, Ljubljana 1000, Slovenia. matjaz.homan@guest.arnes.si
Telephone: +386-1-5229276 Fax: +386-1-5229350
Received: May 18, 2019
Peer-review started: May 20, 2019
First decision: July 21, 2019
Revised: July 29, 2019
Accepted: August 7, 2019
Article in press: August 7, 2019
Published online: September 7, 2019
Peer-review started: May 20, 2019
First decision: July 21, 2019
Revised: July 29, 2019
Accepted: August 7, 2019
Article in press: August 7, 2019
Published online: September 7, 2019
Core Tip
Core tip: The assessment of pathogenicity of a plethora of Helicobacter pylori (H. pylori) virulence genes appears to be relatively difficult. In specific, H. pylori isolates show a high degree of geographic variability, with certain H. pylori genotypes being associated with a more severe clinical outcome in some regions, while presenting as virtually harmless variants in other studied populations. To date, cagA and certain allelic variants of vacA have been most consistently associated with severe gastroduodenal disease in both children and adults, whereas the role of outer membrane proteins, such as babA2, sabA, homB and oipA, is somewhat more ambiguous.