Systematic Reviews
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 28, 2019; 25(32): 4779-4795
Published online Aug 28, 2019. doi: 10.3748/wjg.v25.i32.4779
Liver cirrhosis and left ventricle diastolic dysfunction: Systematic review
Ieva Stundiene, Julija Sarnelyte, Ausma Norkute, Sigita Aidietiene, Valentina Liakina, Laura Masalaite, Jonas Valantinas
Ieva Stundiene, Julija Sarnelyte, Valentina Liakina, Laura Masalaite, Jonas Valantinas, Vilnius University, Institute of Clinical Medicine, Clinic of Gastroenterology, Nephrourology and Surgery, Vilnius University, Vilnius LT-03101, Lithuania
Ausma Norkute, Vilnius University, Institute of Clinical Medicine, Clinic of Internal diseases, Family medicine and Oncology, Vilnius University, Vilnius LT-03101, Lithuania
Sigita Aidietiene, Vilnius University, Institute of Clinical Medicine, Clinic of Cardiology and Angiology, Vilnius University, Vilnius LT-03101, Lithuania
Valentina Liakina, Vilnius Gediminas Technical University, Faculty of Fundamental Sciences, Department of Chemistry and Bioengineering, Vilnius LT-10223, Lithuania
Author contributions: Stundiene I, Sarnelyte J and Norkute A separately reviewed all of the titles, abstracts, full articles and performed data extraction. Aidietiene S and Masalaite L excluded irrelevant articles. Liakina V reviewed extracted data for accuracy. Stundiene I and Sarnelyte J wrote the manuscript with support from Norkute A. Valantinas J, Liakina V and Aidietiene S reviewed and approved the final submitted manuscript.
Conflict-of-interest statement: The authors have no conflicts of interest.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Julija Sarnelyte, MD, Academic Fellow, Clinic of Gastroenterology, Nephrourology and Surgery, Institute of Clinical Medicine, Vilnius University, Universiteto Street 3, Vilnius LT-03101, Lithuania. sarnelyte.julija@gmail.com
Telephone: +370-62602666
Received: April 22, 2019
Peer-review started: April 22, 2019
First decision: May 9, 2019
Revised: June 10, 2019
Accepted: July 19, 2019
Article in press: July 19, 2019
Published online: August 28, 2019
Core Tip

Core tip: In this systematic review we aimed to assess the association between left ventricle diastolic dysfunction and the severity of liver cirrhosis, evaluated by Child-Pugh classes. The proportion of patients with higher diastolic dysfunction grades increases in more severe cirrhosis presentation (P < 0.001). These results suggest that left ventricle diastolic dysfunction and its severity is an attribute of liver cirrhosis. Future directions of a comprehensive assessment of cardiac function in cirrhotic patients might provide a better prognosis to these patients and give hint for better understanding of the left ventricle diastolic dysfunction pathogenesis in liver cirrhosis.