Published online Aug 7, 2019. doi: 10.3748/wjg.v25.i29.3838
Peer-review started: May 7, 2019
First decision: June 9, 2019
Revised: June 14, 2019
Accepted: June 22, 2019
Article in press: June 23, 2019
Published online: August 7, 2019
Core tip: The interest for gut-microbiota is rapidly increasing due to its impact on many physiological and pathological functions. In particular, gut-brain axis, in which commensal microorganisms’ impact, in interplay with immune and endocrine systems, might be a tool and a focus of both scientific investigation and therapeutic interventions. Accordingly, here, by focusing on some examples of multifactorial conditions, such as obesity, we advocate for a redefined health account, in eco-systemic terms, in order to promote a new way of considering the detection of and the approach to diseases. A healthy axis could become part of a more effective perspective towards both person-centered medicine and personalized medicine.