Published online Jul 28, 2019. doi: 10.3748/wjg.v25.i28.3664
Peer-review started: March 18, 2019
First decision: May 9, 2019
Revised: May 20, 2019
Accepted: June 25, 2019
Article in press: June 26, 2019
Published online: July 28, 2019
Core tip: Nonalcoholic fatty liver disease (NAFLD) is more frequent and more severe in patients with type 2 diabetes mellitus (T2DM) than in the general population. Sodium-glucose co-transporter-2 (SGLT2) inhibitors appear to represent a promising option for the management of NAFLD in patients with T2DM. However, existing studies are small, their follow-up period was short and none evaluated the effects of SGLT2 inhibitors on liver histology. Accordingly, larger studies are needed to verify these preliminary results and define the role of SGLT2 inhibitors in the treatment of NAFLD in patients with T2DM.