Published online Jul 14, 2019. doi: 10.3748/wjg.v25.i26.3299
Peer-review started: March 18, 2019
First decision: April 16, 2019
Revised: May 10, 2019
Accepted: May 18, 2019
Article in press: May 18, 2019
Published online: July 14, 2019
Core tip: Hepatitis B virus (HBV) reactivation frequently exerts a negative impact on the outcome of patients with hemo-lymphoproliferative disorders both by liver injury, at times severe, and a premature delay or termination of immunosuppressive treatments. Patients at risk should be identified by screening of HBV serum markers before immunosuppressive therapy is started. The use of HBV nucle(t)side analogues, as treatment or prophylaxis, is effective in limiting the frequency and intensity of the damage caused. Antivirals should be administered 2-3 wk before starting immunosuppressive treatment, for the entire immunosuppressive period and during post-treatment follow-up, the length of which depends on the intensity of immunosuppression reached.