Nuclear magnetic resonance-based metabolomics and metabolic pathway networks from patient-matched esophageal carcinoma, adjacent noncancerous tissues and urine
Jia-Hao Liang, Yan Lin, Ting Ouyang, Wan Tang, Yao Huang, Wei Ye, Jia-Yun Zhao, Zhe-Ning Wang, Department of Radiology, Second Affiliated Hospital, Shantou University Medical College, Shantou 515041, Guangdong Province, China
Chang-Chun Ma, Department of Radiation Oncology, Affiliated Tumor Hospital, Shantou University Medical College, Shantou 515041, Guangdong Province, China
Author contributions: Lin Y conceived and designed the experiments; Liang JH and Lin Y contributed to NMR data acquisition; Liang JH, Ouyang T, Tang W and Huang Y analyzed the data; Lin Y wrote the paper; Ye W, Zhao JY and Wang ZN contributed to sample preparation; all authors approved the final version of the manuscript for publication.
Supported by the National Natural Science Foundation of China, No. 81471729 and No. 81101102; the Science and Technology and Planning Project of Guangdong Province, No. 2016A020216025; the Research Award Fund for Outstanding Young Teachers in Higher Education Institutions, Guangdong Province, No. YQ2015245; the National Natural Science Foundation of Guangdong Province, No. S2011010004973; the Department of Education of Guangdong Province, No. 2017KTSCX071.
Institutional review board statement: This study was reviewed and approved by the Second Affiliated Hospital, Shantou University Medical College Review Board (2018-44).
Informed consent statement: Informed consent was obtained from each subject prior to participation in this study.
Conflict-of-interest statement: The authors declare that they have no competing interests related to this study.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Yan Lin, PhD, Chief Doctor, Department of Radiology, Second Affiliated Hospital, Shantou University Medical College, No. 69. Dongshabei Road, Shantou 515041, Guangdong Province, China. firstname.lastname@example.org
Received: January 25, 2019
Peer-review started: January 25, 2019
First decision: February 26, 2019
Revised: May 13, 2019
Accepted: May 31, 2019
Article in press: June 1, 2019
Published online: July 7, 2019