Sporamin suppresses growth of xenografted colorectal carcinoma in athymic BALB/c mice by inhibiting liver β-catenin and vascular endothelial growth factor expression
Chun Yang, Jing-Jie Zhang, Xiao-Peng Zhang, Rong Xiao, Peng-Gao Li, School of Public Health, Capital Medical University, Beijing Key Laboratory of Clinical Epidemiology, Beijing 100069, China
Author contributions: Yang C and Zhang JJ contributed equally to the work and should be regarded as co-first authors; Li PG designed the research; Zhang JJ and Zhang XP performed the research; Yang C and Zhang JJ analyzed the data and wrote the paper; Xiao R revised the manuscript; Li PG has primary responsibility for the final content.
Supported by the National Natural Science Foundation of China, No. 81573128 and No. 81703216.
Institutional animal care and use committee statement: This study was approved by the institutional animal care and use committee of Capital Medical University.
Conflict-of-interest statement: The authors declare no conflicts of interest.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Peng-Gao Li, PhD, Associate Professor, School of Public Health, Capital Medical University, Beijing Key Laboratory of Clinical Epidemiology, 10 Xitoutiao, You An Men Wai, Fengtai District, Beijing 100069, China. email@example.com
Telephone: +86-10-83911651 Fax: +86-10-83911651
Received: February 23, 2019
Peer-review started: February 23, 2019
First decision: April 4, 2019
Revised: May 14, 2019
Accepted: May 31, 2019
Article in press: June 1, 2019
Published online: July 7, 2019