Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 7, 2019; 25(25): 3183-3195
Published online Jul 7, 2019. doi: 10.3748/wjg.v25.i25.3183
Infections with Helicobacter pylori and challenges encountered in Africa
Stella Smith, Muinah Fowora, Rinaldo Pellicano
Stella Smith, Muinah Fowora, Department of Molecular Biology and Biotechnology, Nigerian Institute of Medical Research, Lagos PMB 2013, Nigeria
Rinaldo Pellicano, Unit of Gastroenterology, Molinette Hospital, Turin 10126, Italy
Author contributions: Smith S and Pellicano R contributed equally to the concept and design of the study; while all authors were involved in the literature review and analysis, drafting and critical revision and editing and final approval of the final version.
Conflict-of-interest statement: No potential conflict of interest and no financial support.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Stella Smith, PhD, Director (Research), Department of Molecular Biology and Biotechnology, Nigerian Institute of Medical Research, 6 Edmond Crescent, Yaba, Lagos PMB 2013, Nigeria.
Telephone: +234-803-7058989
Received: March 17, 2019
Peer-review started: March 18, 2019
First decision: April 4, 2019
Revised: May 2, 2019
Accepted: May 31, 2019
Article in press: June 1, 2019
Published online: July 7, 2019
Core Tip

Core tip: Africa has the highest rates of global prevalence of Helicobacter pylori (H. pylori) infection worldwide. Nevertheless, scarce data are available, describing in some cases both inappropriate diagnostic approaches and therapeutic regimens. This probably depends on the lack of continental consensus guideline for the management of H. pylori infection. As a consequence, there is an increasing number of papers reporting, in several countries, a high rate of bacterial resistance to the most commonly used antibiotics for H. pylori treatment. This manuscript gives an update on the African literature about H. pylori infection and on the present and future challenges in this context.