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©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 14, 2019; 25(22): 2776-2787
Published online Jun 14, 2019. doi: 10.3748/wjg.v25.i22.2776
Published online Jun 14, 2019. doi: 10.3748/wjg.v25.i22.2776
Sp1 contributes to overexpression of stanniocalcin 2 through regulation of promoter activity in colon adenocarcinoma
Ji-Bin Li, Zhe-Xian Liu, Rui Zhang, Si-Ping Ma, Tao Lin, Yan-Xi Li, Shi-Hua Yang, Wan-Chuan Zhang, Yong-Peng Wang, Department of Colorectal Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang 110042, Liaoning Province, China
Shi-Hua Yang, Wan-Chuan Zhang, China Medical University, Shenyang 110000, Liaoning Province, China
Author contributions: Li JB and Liu ZX contributed equally to this study; Li JB, Liu ZX, Zhang R, Ma SP, Lin T, and Li YX conducted the experiments and data analysis.; Yang SH and Zhang WC provided technical support and participated in the project discussion; Yang SH and Liu ZX drafted the manuscript; Li JB, Zhang R, and Wang YP designed and directed the project; All authors read and approved the submission of the manuscript.
Supported by: the Natural Science Foundation of Liaoning Province , China, No. 20180550769 .
Institutional review board statement: This study was reviewed and approved by the Institutional Review Board of Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute.
Conflict-of-interest statement: The authors declare no conflict of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Yong-Peng Wang, MD, Director, Department of Colorectal Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, NO. 44, Xiaoheyan Road, Dadong District, Shenyang 110042, Liaoning Province, China. zzzrrr1234@sina.com
Telephone: +86-24-24315679 Fax: +86-24-24315679
Received: March 27, 2019
Peer-review started: March 27, 2019
First decision: April 17, 2019
Revised: April 22, 2019
Accepted: April 29, 2019
Article in press: April 29, 2019
Published online: June 14, 2019
Peer-review started: March 27, 2019
First decision: April 17, 2019
Revised: April 22, 2019
Accepted: April 29, 2019
Article in press: April 29, 2019
Published online: June 14, 2019
Core Tip
Core tip: This study demonstrated that stanniocalcin 2 (STC2) is overexpressed in colon adenocarcinoma (COAD) and that high expression of STC2 predicts poor prognosis. The promoter of STC2 in COAD was hypermethylated, and the transcription factor Sp1 was essential for STC2 expression. These findings provide new insights into the mechanism of oncogenic function of STC2 in COAD.