Observational Study
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 7, 2019; 25(21): 2665-2674
Published online Jun 7, 2019. doi: 10.3748/wjg.v25.i21.2665
Management of betablocked patients after sustained virological response in hepatitis C cirrhosis
Marta Abadía, María Luisa Montes, Dolores Ponce, Consuelo Froilán, Miriam Romero, Joaquín Poza, Teresa Hernández, Rubén Fernández-Martos, Antonio Olveira, on behalf of the “La Paz Portal Hypertension” Study Group Investigators
Marta Abadía, Consuelo Froilán, Miriam Romero, Joaquín Poza, Rubén Fernández-Martos, Antonio Olveira, Servicio de Aparato Digestivo, Hospital Universitario La Paz, Madrid 28046, Spain
María Luisa Montes, Unidad VIH, Servicio de Medicina Interna, Hospital Universitario La Paz, Madrid 28046, Spain
Dolores Ponce, Teresa Hernández, Servicio de Radiología, Hospital Universitario La Paz, Madrid 28046, Spain
Author contributions: Abadía M, Montes ML, and Olveira A designed the research; Abadía M, Montes ML, Ponce D, Froilán C, Romero M, Poza J, Hernández T, Fernández-Martos R, Olveira A and the remaining “La Paz Portal Hypertension” Study Group Investigators (Castillo P, Erdozain JC, García-Samaniego J, González J, Gonzalo N, García A, Marín E, Martín-Carbonero L, Mora P, Novo J, Fernández-Rodríguez L, Valencia E) performed the research; Abadía M, Montes ML, Froilán C, and Olveira A analyzed the data; Abadía M, Montes ML, and Olveira A wrote the paper.
Supported by RIS (Red Temática de Investigación Cooperativa en SIDA) RD16/0025/0018 (translation and statistical analysis);the RIS is funded by the Instituto de Salud Carlos III as part of the Plan Nacional R + D + I and cofinanced by ISCIII-Subdirección General de Evaluación and the Fondo Europeo de Desarrollo Regional (FEDER).
Institutional review board statement: The study was reviewed and approved by the Human Research and Ethics Committee at Hospital Universitario La Paz (Madrid).
Informed consent statement: Written informed consent was obtained from each patient included in the study.
Conflict-of-interest statement: The authors have no conflict of interest to declare.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Marta Abadía, MD, Doctor, Servicio de Aparato Digestivo, Hospital Universitario La Paz, Paseo de La Castellana 261, Madrid 28046, Spain. mabadiab@gmail.com
Telephone: +34-646388528 Fax: +34-912071466
Received: February 17, 2019
Peer-review started: February 18, 2019
First decision: March 5, 2019
Revised: March 13, 2019
Accepted: March 24, 2019
Article in press: March 25, 2019
Published online: June 7, 2019
Core Tip

Core tip: Approximately 1/3 of the patients with baseline cirrhosis and bleeding-risk oesophageal varices, satisfactorily evolve below the bleeding-risk threshold, after curation of chronic hepatitis C. In these patients, the definitive interruption of the preventive medication taken to avoid bleeding seems to be safe.