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©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 14, 2019; 25(18): 2149-2161
Published online May 14, 2019. doi: 10.3748/wjg.v25.i18.2149
Published online May 14, 2019. doi: 10.3748/wjg.v25.i18.2149
Alteration of the esophageal microbiota in Barrett's esophagus and esophageal adenocarcinoma
Jing Lv, He-Ping Zhao, Ji-Han Wang, Department of Clinical Laboratory, Honghui Hospital, Xi'an Jiaotong University, Xi'an 710054, Shaanxi Province, China
Lei Guo, Ji-Jun Liu, Department of Spinal Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi'an 710054, Shaanxi Province, China
Jun Zhang, Department of Gastroenterology, Second Affiliated Hospital of Xi’an Jiaotong University, Xi'an 710004, Shaanxi Province, China
Author contributions: Lv J and Guo L searched and reviewed published articles and wrote the manuscript; Liu JJ and Zhao HP conducted online data searches, critically reviewed the article and made revisions to the manuscript; Wang JH and Zhang J made substantial contributions to the conception and design of the study and approved the final version of the article to be published.
Supported by: the National Natural Science Foundation of China , No. 81702067 ; Shaanxi Natural Science Foundation of China , No. 2018JQ8029 ; and Shaanxi Natural Science Foundation of China , No. 2017JQ8041 .
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Ji-Han Wang, PhD, Doctor, Department of Clinical Laboratory, Honghui Hospital, Xi'an Jiaotong University, No.555 You Yi Dong Road, Xi'an 710054, Shaanxi Province, China. 513837742@qq.com
Telephone: +86-029-62818664 Fax: +86-029-87889576
Received: February 12, 2019
Peer-review started: February 14, 2019
First decision: March 20, 2019
Revised: March 27, 2019
Accepted: April 10, 2019
Article in press: April 11, 2019
Published online: May 14, 2019
Peer-review started: February 14, 2019
First decision: March 20, 2019
Revised: March 27, 2019
Accepted: April 10, 2019
Article in press: April 11, 2019
Published online: May 14, 2019
Core Tip
Core tip: Esophageal adenocarcinoma (EAC) is a malignancy with poor prognosis, and Barrett's esophagus (BE) is the only recognized precursor. As part of the human gut, the esophagus harbors distinctive microbiota, and dysbiosis may be related to BE/EAC. Many studies have attempted to characterize the esophageal microbiota in the normal esophagus and in different diseases, but more data are required. Studies on the esophageal microbiota in BE/EAC have mainly concentrated on these associations, and the underlying mechanisms remain blurred. This review focuses on the features and associations of esophageal microbiota and BE/EAC, which might provide some evidence of their relationships.