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©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 7, 2019; 25(17): 2086-2098
Published online May 7, 2019. doi: 10.3748/wjg.v25.i17.2086
Published online May 7, 2019. doi: 10.3748/wjg.v25.i17.2086
Analysis of the autophagy gene expression profile of pancreatic cancer based on autophagy-related protein microtubule-associated protein 1A/1B-light chain 3
Yan-Hui Yang, Yang Gui, Jun-Jun Sun, Department of Hepatobiliary Surgery, First Affiliated Hospital, College of Clinical Medicine, Henan University of Science and Technology, Luoyang 471000, Henan Province, China
Yu-Xiang Zhang, Department of Urology Surgery, First Affiliated Hospital, College of Clinical Medicine, Henan University of Science and Technology, Luoyang 471000, Henan Province, China
Jiang-Bo Liu, Department of General Surgery, First Affiliated Hospital, College of Clinical Medicine, Henan University of Science and Technology, Luoyang 471000, Henan Province, China
Hua Fan, First Affiliated Hospital, College of Clinical Medicine, Henan University of Science and Technology, Luoyang 471000, Henan Province, China
Author contributions: Yang YH, Sun JJ and Fan H designed the research; Zhang YH and Gui Y performed the research; Liu JB contributed novel reagents; Fan H analyzed the data; Yang YH, Zhang YX and Gui Y wrote the paper; Fan H and Yang YH performed critical revision of the manuscript.
Supported by the National Natural Science Foundation of China , No. U1504815 and No. U1504808 .
Institutional review board statement: The study was reviewed and approved by the First Affiliated Hospital of Zhengzhou University Institutional Review Board.
Conflict-of-interest statement: The authors declare no competing interests.
Data sharing statement: No additional unpublished data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Hua Fan, PhD, Academic Fellow, First Affiliated Hospital, College of Clinical Medicine, Henan University of Science and Technology, No. 24 Jing-Hua Road, Luoyang 471003, Henan Province, China. fanhua19851229@haust.edu.cn
Telephone: +86-379-64830681 Fax: +86-379-64830681
Received: January 9, 2019
Peer-review started: January 10, 2019
First decision: February 26, 2019
Revised: March 20, 2019
Accepted: April 10, 2019
Article in press: April 10, 2019
Published online: May 7, 2019
Peer-review started: January 10, 2019
First decision: February 26, 2019
Revised: March 20, 2019
Accepted: April 10, 2019
Article in press: April 10, 2019
Published online: May 7, 2019
Core Tip
Core tip: In this study, we identified differentially expressed genes based on the autophagy-related protein microtubule-associated protein 1A/1B-light chain 3 (LC3) to analyze the gene expression profile of autophagy in pancreatic cancer. Three hundred and forty-seven genes that have no confirmed association with the autophagy process of human pancreatic cancer cells in previous studies were concentrated, and the key pathways involved in autophagy were enriched. Furthermore, a key gene ubiquitin C which is closely related to the occurrence of perineural invasion (PNI) was determined, suggesting that LC3 may influence the PNI and prognosis of pancreatic cancer through ubiquitin C.