Published online Apr 7, 2019. doi: 10.3748/wjg.v25.i13.1560
Peer-review started: January 8, 2019
First decision: February 13, 2019
Revised: February 28, 2019
Accepted: March 1, 2019
Article in press: March 2, 2019
Published online: April 7, 2019
Core tip: Cellular therapy may be the solution of challenging problems in colorectal surgery such as impaired healing leading to anastomotic leakage and metastatic colorectal cancer. Two types of cellular therapy have been recognized, the mesenchymal stem cells (MSCs) and bone marrow-mononuclear cells therapy. These cells have been shown to accelerate and promote healing of various tissue injuries in animal and human studies. In addition, experimental studies have reported that MSCs may help suppress the progression of colon cancer in rat models.