Serum Mac-2 binding protein glycosylation isomer level predicts hepatocellular carcinoma development in E-negative chronic hepatitis B patients
Lung-Yi Mak, Wai-Pan To, James Fung, Department of Medicine, Queen Mary Hospital, Hong Kong, China
Danny Ka-Ho Wong, Fen Liu, Wai-Kay Seto, Ching-Lung Lai, Man-Fung Yuen, Department of Medicine, The University of Hong Kong, Hong Kong, China
Danny Ka-Ho Wong, James Fung, Wai-Kay Seto, Ching-Lung Lai, Man-Fung Yuen, State Key Laboratory for Liver Research, The University of Hong Kong, Hong Kong, China
Author contributions: Mak LY and To WP were involved in drafting the manuscript. Wong DKH was involved in performing laboratory tests and collecting the data. Fung J was involved in data acquisition, statistical analysis, and language editing of the manuscript. Seto WK was involved in interpretation of the data and critical revision of the manuscript. Lai CL was involved in critical revision of the manuscript. Yuen MF was involved in study concept and design, analysis and interpretation of data, critical revision of manuscript, and overall study supervision. All authors have approved the final draft submitted.
Institutional review board statement: This study was reviewed and approved by the Institutional Review Board/ Ethics Committee of the University of Hong Kong and the Hong Kong West Cluster of Hospital Authority.
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data and stored serum samples that were obtained after each patient agreed to such storage for clinical research by informed consent in previous studies.
Conflict-of-interest statement: All authors declare no conflicts-of-interest related to this article.
Data sharing statement: No additional data are available.
Open-Access: This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Man-Fung Yuen, DSc, FRCP (C), MBBS, MD, MRCP, PhD, Professor, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Pokfulam Road 102, Hong Kong, China. firstname.lastname@example.org
Telephone: +86-852-22553994 Fax: +86-852-28162863
Received: December 15, 2018
Peer-review started: December 17, 2018
First decision: January 6, 2019
Revised: January 22, 2019
Accepted: January 26, 2019
Article in press: January 26, 2019
Published online: March 21, 2019