Basic Study
Copyright ©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 14, 2018; 24(6): 671-679
Published online Feb 14, 2018. doi: 10.3748/wjg.v24.i6.671
Health-related quality of life, anxiety, depression and impulsivity in patients with advanced gastroenteropancreatic neuroendocrine tumours
Alexandra R Lewis, Xin Wang, Laurice Magdalani, Paolo D’Arienzo, Colsom Bashir, Was Mansoor, Richard Hubner, Juan W Valle, Mairéad G McNamara
Alexandra R Lewis, Laurice Magdalani, Was Mansoor, Richard Hubner, Juan W Valle, Mairéad G McNamara, Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester M20 4BX, United Kingdom
Xin Wang, Department of Biostatistics, The Christie NHS Foundation Trust, Manchester M20 4BX, United Kingdom
Paolo D’Arienzo, Division of Medical Sciences, Scuola Superiore Sant’Anna, Pisa 56127, Italy
Colsom Bashir, Department of Clinical Psychology, The Christie NHS Foundation Trust, Manchester M20 4BX, United Kingdom
Juan W Valle, Mairéad G McNamara, Division of Cancer Sciences, University of Manchester, Manchester M20 4BX, United Kingdom
Author contributions: Study design was by Lewis AR, Valle JW and McNamara MG with contributions from Bashir C; Data was collected by Lewis AR and Magdalani L; Data was analysed by Wang X; The manuscript was written by D’Arienzo P and Lewis AR and reviewed and revised by Wang X, Bashir C, Hubner R, Mansoor W, Valle JW and McNamara MG.
Institutional review board statement: CE16/1619 Quality of life, impulsivity, anxiety and depression in patients with Gastroenteropancreatic Neuroendocrine tumours (GEPNETs) approved by Clinical Audit committee 20.04.2016
Conflict-of-interest statement: There are no conflicts of interest to declare.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at Mairead.McNamara@christie.nhs.uk. Consent for data sharing was not obtained but the presented data are anonymized and risk of identification is low.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Mairéad G McNamara, MB, BCh, BAO, PhD, Attending Doctor, Senior Lecturer, Department of Medical Oncology, The Christie NHS Foundation Trust, 550 Wilmslow Road, Manchester M20 4BX, United Kingdom. mairead.mcnamara@christie.nhs.uk
Telephone: +44-161-4468106 Fax: +44-161-4463468
Received: October 25, 2017
Peer-review started: October 27, 2017
First decision: November 21, 2017
Revised: December 11, 2017
Accepted: December 20, 2017
Article in press: December 20, 2017
Published online: February 14, 2018
Core Tip

Core tip: Patients with functioning gastroenteropancreatic neuroendocrine tumours (GEPNETs) may have higher levels of psychological distress than other patients with cancer due to the symptoms of hormone hypersecretion. This study compares 25 patients with advanced GEPNET and carcinoid syndrome (CS) with 25 patients with advanced, but non-functioning GEPNET. Symptoms of anxiety, depression, impulsivity and health-related quality of life were assessed prospectively using symptom scales. Endocrine symptoms were significantly higher in patients with CS. Disease-related worries were more common in those with non-functioning tumours. This is a large study in this rare patient group and further prospective studies are required.