Basic Study
Copyright ©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 7, 2018; 24(5): 573-582
Published online Feb 7, 2018. doi: 10.3748/wjg.v24.i5.573
Hsa-miR-202-3p, up-regulated in type 1 gastric neuroendocrine neoplasms, may target DUSP1
Dou Dou, Yan-Fen Shi, Qing Liu, Jie Luo, Ji-Xi Liu, Meng Liu, Ying-Ying Liu, Yuan-Liang Li, Xu-Dong Qiu, Huang-Ying Tan
Dou Dou, Yuan-Liang Li, Xu-Dong Qiu, Department of Integrative Oncology, China-Japan Friendship Hospital; Beijing University of Chinese Medicine, Beijing 100029, China
Yan-Fen Shi, Jie Luo, Department of Pathology, China-Japan Friendship Hospital, Beijing 100029, China
Qing Liu, Meng Liu, Huang-Ying Tan, Department of Integrative Oncology, China-Japan Friendship Hospital, Beijing 100029, China
Ji-Xi Liu, Department of Gastroenterology, China-Japan Friendship Hospital, Beijing 100029, China
Ying-Ying Liu, Department of Integrative Oncology, Luoyang Central Hospital Affiliated to Zhengzhou University, Luoyang 471009, Henan Province, China
Author contributions: Dou D and Shi YF contributed equally to this work and should be considered co-first authors; Tan HY, Dou D and Shi YF designed the research; Dou D, Liu Q, Liu JX, and Li YL performed the research; Shi YF, Luo J and Qiu XD analyzed the data; Dou D, Liu M and Liu YY wrote the paper; Shi YF and Tan HY revised the paper.
Supported by the National Natural Science Foundation of China, No. 81673763.
Institutional review board statement: The study was reviewed and approved by the China-Japan Friendship Hospital Institutional Review Board.
Conflict-of-interest statement: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the reported research.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Huang-Ying Tan, MD, PhD, Professor, Department of Integrative Oncology, China-Japan Friendship Hospital, No. 2, Yinghuadong Street, Beijing 100029, China. tanhuangying@263.net
Telephone: +86-10-53236555 Fax: +86-10-53236555
Received: November 5, 2017
Peer-review started: November 6, 2017
First decision: November 22, 2017
Revised: December 3, 2017
Accepted: December 12, 2017
Article in press: December 12, 2017
Published online: February 7, 2018
Core Tip

Core tip: In this study, we have innovatively used chip technology to study microRNAs in type 1 gastric neuroendocrine neoplasms. We found miR-202-3p was extraordinarily upregulated in the tumours compared to the control samples. Interestingly, although miR-202 belongs to let-7, a famous cancer-suppressing family, some studies have reported its oncogenic potential in some tumours. Then, we found that DUSP1 could be a target gene of miR-202-3p and was closely related to tumour occurrence and development. Finally, we successfully showed that the miR-202-3p directly regulated DUSP1 in tool cells.