Integrated metabolomic profiling for analysis of antilipidemic effects of Polygonatum kingianum extract on dyslipidemia in rats
Xing-Xin Yang, Jia-Di Wei, Jian-Kang Mu, Xin Liu, Jin-Cai Dong, Lin-Xi Zeng, Wen Gu, Jing-Ping Li, Jie Yu
Xing-Xin Yang, Jia-Di Wei, Jian-Kang Mu, Jin-Cai Dong, Lin-Xi Zeng, Wen Gu, Jing-Ping Li, Jie Yu, College of Pharmaceutical Science, Yunnan University of Traditional Chinese Medicine, Kunming 650500, Yunnan Province, China
Xin Liu, Beijing Entry-Exit Inspection and Quarantine Bureau, Beijing 100026, China
Author contributions: Yang XX and Yu J designed the research; Yang XX, Wei JD and Dong JC performed the research; Liu X contributed analytic tools; Zeng LX, Gu W and Li JP analyzed the data; Yang XX, Wei JD and Mu JK wrote the paper.
Supported by the National Natural Science Foundation of China, No. 81660596 and No. 81760733; the Application and Basis Research Project of Yunnan, China, No. 2016FD050 and No. 2017FF117-013; and the Fund for Young and Middle-aged Academic and Technological Leaders of Yunnan, No. 2015HB053.
Institutional animal care and use committee statement: Approval from the Institutional Ethical Committee on Animal Care and Experimentations of Yunnan University of Traditional Chinese Medicine was obtained for this study.
Conflict-of-interest statement: The authors declare that there is no duality of interest associated with this manuscript.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The authors had read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Jie Yu, PhD, Professor, College of Pharmaceutical Science, Yunnan University of Traditional Chinese Medicine, 1076 Yuhua Road, Kunming 650500, Yunnan Province, China. cz.yujie@gmail.com
Telephone: +86-871-65933303 Fax: +86-871-65933303
Received: September 25, 2018
Peer-review started: September 25, 2018
First decision: October 24, 2018
Revised: October 31, 2018
Accepted: November 16, 2018
Article in press: November 16, 2018
Published online: December 28, 2018
