Minireviews
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World J Gastroenterol. Dec 28, 2018; 24(48): 5454-5461
Published online Dec 28, 2018. doi: 10.3748/wjg.v24.i48.5454
Post-translational modifications of prostaglandin-endoperoxide synthase 2 in colorectal cancer: An update
Rafael I Jaén, Patricia Prieto, Marta Casado, Paloma Martín-Sanz, Lisardo Boscá
Rafael I Jaén, Patricia Prieto, Lisardo Boscá, Department of Metabolism and Physiopathology of Inflammatory Diseases, Instituto de Investigaciones Biomédicas Alberto Sols (CSIC-UAM), Madrid 28029, Spain
Marta Casado, Department of Biomedicine, Instituto de Biomedicina de Valencia (CSIC), Valencia 46010, Spain
Marta Casado, Paloma Martín-Sanz, Lisardo Boscá, Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares, y Hepáticas y Digestivas, ISCIII, Madrid 28029, Spain
Paloma Martín-Sanz, Lisardo Boscá, Unidad Asociada IIBM-ULPGC, Universidad de las Palmas de Gran Canaria (ULPGC), Las Palmas de Gran Canaria 35001, Spain
Author contributions: Jaén RI and Prieto P contributed equally to the discussion of the minireview and provided key information on the glycosylation of prostaglandin-endoperoxide synthase 2 in colorectal cancer samples. Casado M, Martín-Sanz P and Boscá L revised the literature, organized the content of the minireview and prepared the figures of the manuscript.
Supported by Ministerio de Ciencia Innovación y Universidades, No. SAF2017-82436R and SAF2016-75004R; Comunidad de Madrid, No. S2017/BMD-3686; Fundación Ramón Areces, No. 2016/CIVP18A3864; and Instituto de Salud Carlos III and by Fondos FEDER, No. Cibercv and Ciberehd.
Conflict-of-interest statement: The authors have declared no conflicts of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Lisardo Boscá, BM, BCh, PhD, Senior Research Fellow, Department of Metabolism and Physiopathology of Inflammatory Diseases, Instituto de Investigaciones Biomédicas Alberto Sols, Arturo Duperier 4, Madrid 28029, Spain. lbosca@iib.uam.es.
Telephone: +34-91-4972747 Fax: +34-91-4972747
Received: October 7, 2018
Peer-review started: October 7, 2018
First decision: November 7, 2018
Revised: November 13, 2018
Accepted: November 13, 2018
Article in press: November 16, 2018
Published online: December 28, 2018
Core Tip

Core tip: The post-translational modifications of prostaglandin-endoperoxide synthase 2 (PTGS2) appear to be specific signatures of this enzyme in human colorectal cancer (CRC). Glycosylations of PTGS2 that alter the electrophoretic mobility of the protein are mainly observed in the tumor samples but are absent in the non-tumor samples obtained from these patients. These modifications not only may play a pathophysiological role in the progression of CRC but also may provide new biomarkers to develop specific therapeutic interventions.