Typing of pancreatic cancer-associated fibroblasts identifies different subpopulations
Michael Friberg Bruun Nielsen, Sönke Detlefsen, Department of Pathology, Odense University Hospital, Department of Clinical Research, University of Southern Denmark, Odense Pancreas Center (OPAC), Odense C 5000, Denmark
Michael Bau Mortensen, Department of Surgery, HPB Section, Odense University Hospital, Department of Clinical Research, University of Southern Denmark, Odense Pancreas Center (OPAC), Odense C 5000, Denmark
Author contributions: Mortensen MB and Detlefsen S initiated the study; Detlefsen S conceptualized the study; Nielsen MFB and Detlefsen S designed and coordinated the experiments; Nielsen MFB and Detlefsen S performed a majority of the experiments; Nielsen MFB and Detlefsen S evaluated the results; Nielsen MFB, Mortensen MB and Detlefsen S discussed and interpreted the data; Nielsen MFB and Detlefsen S wrote the manuscript; Nielsen MFB, Mortensen MB and Detlefsen S critically revised the manuscript.
Supported by Aase-and-Ejnar Danielsen’s Foundation, No. 10-001452; Brødrene Hartmann’s Foundation, No. A28308; the Foundation of 17.12.1981, No. 19024005; Karen S. Jensens Grant, No. 27-A1433; University of Southern Denmark Faculty Scholarship; Odense University Hospital Free Research Fund, No. 29-A1500, 22-A1133 and 49-A2379; Odense University Hospital Ph.D. stipend, No. 1032; and Odense Pancreas Center (OPAC).
Institutional review board statement: The study was approved by the Ethical Committee of the Region of Southern Denmark (project ID: S-20140168 and project ID: S-20150130).
Conflict-of-interest statement: The authors declare no conflict of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Sönke Detlefsen, MD, PhD, Associate Professor, Department of Pathology, Odense University Hospital, University of Southern Denmark, J.B. Winsløws Vej 15, Odense C 5000, Denmark. firstname.lastname@example.org
Telephone: +45-65414806 Fax: +45-65912943
Received: July 23, 2018
Peer-review started: July 23, 2018
First decision: August 25, 2018
Revised: October 12, 2018
Accepted: October 21, 2018
Article in press: October 21, 2018
Published online: November 7, 2018