Observational Study
Copyright ©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Oct 28, 2018; 24(40): 4606-4614
Published online Oct 28, 2018. doi: 10.3748/wjg.v24.i40.4606
Long term outcome of antiviral therapy in patients with hepatitis B associated decompensated cirrhosis
Young-Cheol Ju, Dae-Won Jun, Jun Choi, Waqar Khalid Saeed, Hyo-Young Lee, Hyun-Woo Oh
Young-Cheol Ju, Dae-Won Jun, Department of Translational Medicine, Graduate school of Biomedical Science and Engineering, Hanyang University, Seoul 04763, South Korea
Dae-Won Jun, Waqar Khalid Saeed, Hyo-Young Lee, Hyun-Woo Oh, Department of Internal Medicine, School of Medicine, Hanyang University, Seoul 04763, South Korea
Jun Choi, Department of Industrial Management Engineering, Korea University, Seoul 02841, South Korea
Author contributions: Jun DW designed and supervised the study; Lee HY, Oh HW independently validated the operational definitions; Choi J collected the HIRA data and analyzed the data; Ju YC wrote the manuscript.
Supported by The Research Supporting Program of The Korean Association for the Study of the Liver and The Korean Liver Foundation.
Institutional review board statement: This study was reviewed and approved by the Institutional Review Board of Hanyang University Hospital (Seoul).
Informed consent statement: This study used insurance reimbursement claims data provided by the Health Insurance Review and Assessment (HIRA). It did not need to make sure of informed written consent prior to study enrollment because the data was already encrypted personal identifiable information.
Conflict-of-interest statement: There are no conflicts of interest to report
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dae-Won Jun, MD, PhD, Professor, Department of Internal Medicine, School of Medicine, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul 04763, South Korea. noshin@hanyang.ac.kr
Telephone: +82-2-22908338 Fax: +82-2-9720068
Received: July 23, 2018
Peer-review started: July 23, 2018
First decision: August 25, 2018
Revised: September 6, 2018
Accepted: October 5, 2018
Article in press: October 5, 2018
Published online: October 28, 2018
Core Tip

Core tip: It is well known that antiviral treatment improves clinical outcomes of chronic hepatitis B-associated decompensated cirrhosis. However, long term and large scale clinical data regarding survival rate, and incidence of hepatocellular carcinoma in patients with decompensated cirrhosis in the antiviral era are lacking. We investigated the survival rate and incidence of hepatocellular carcinoma (HCC) in patients with decompensated cirrhosis by using the Health Insurance Review and Assessment database. Long term outcome of treating hepatitis B-associated decompensated cirrhosis using antiviral agents improved much compare to previous reports. Cumulative mortality rate and incidence of HCC was sharply decreased after one year antiviral treatment.