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Copyright ©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Oct 21, 2018; 24(39): 4436-4447
Published online Oct 21, 2018. doi: 10.3748/wjg.v24.i39.4436
Carcinogenesis on the background of liver fibrosis: Implications for the management of hepatocellular cancer
Joanne Marie O’Rourke, Vandana Mridhu Sagar, Tahir Shah, Shishir Shetty
Joanne Marie O’Rourke, Vandana Mridhu Sagar, Shishir Shetty, Centre for Liver Research, Institute of Biomedical Research, Birmingham B15 2TT, United Kingdom
Joanne Marie O’Rourke, Vandana Mridhu Sagar, Tahir Shah, Shishir Shetty, NIHR Birmingham Biomedical Research Centre, University of Birmingham and University Hospitals Birmingham NHS Foundation Trust, United Kingdom
Author contributions: Shetty S contributed to review concept, literature review and writing the paper; O’Rourke JM contributed to the literature review and writing the paper; Sagar VM and Shah T provided critical intellectual revisions and editing of the manuscript.
Conflict-of-interest statement: No potential conflicts of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Shishir Shetty, MBChB, MRCP, PhD, Senior Research Fellow, Centre for Liver Research, Institute of Biomedical Research, University of Birmingham, Birmingham B15 2TT, United Kingdom. s.shetty@bham.ac.uk
Telephone: +44-121-3714852
Received: May 9, 2018
Peer-review started: May 9, 2018
First decision: June 15, 2018
Revised: September 3, 2018
Accepted: October 5, 2018
Article in press: October 5, 2018
Published online: October 21, 2018
Core Tip

Core tip: In this review, we discuss the development of hepatocellular carcinoma in the setting of liver inflammation and fibrosis, reviewing the microenvironment that leads to this tumorigenic climate and the implications this has for patient management.