Altered oral microbiota in chronic hepatitis B patients with different tongue coatings
Yu Zhao, Yu-Feng Mao, Yi-Shuang Tang, Ming-Zhu Ni, Qiao-Hong Liu, Yan Wang, Qin Feng, Jing-Hua Peng, Institute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
Yi-Yang Hu, Institute of Liver Diseases, Key Laboratory of Liver and Kidney Diseases (Ministry of Education), Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
Author contributions: Hu YY designed the study; Zhao Y and Tang YS performed the tongue coating microbial experiments; Tang YS, Liu QH and Wang Y performed the tongue coating metabolic experiments; Tang YS, Feng Q and Peng JH performed the clinical trial; Mao YF and Ni MZ performed the statistical analyses; Zhao Y wrote the paper.
Supported by the Shanghai Educational Development Foundation, No. 14CG41; the National Natural Science Foundation of China, No. 81403298 and No. 81373857; and the National Key New Drug Creation Project, No. 2017ZX09304002.
Institutional review board statement: The study was reviewed and approved by the IRB of Shuguang Hospital affiliated with the Shanghai University of TCM Institutional Review Board.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: There are no conflicts of interest to report.
STROBE statement: The authors have read the STROBE Statement checklist of items, and the manuscript was prepared and revised according to the STROBE Statement checklist of items.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Yi-Yang Hu, MD, PhD, Doctor, Senior Researcher, Institute of Liver Diseases, Key Laboratory of Liver and Kidney Diseases (Ministry of Education), Shuguang Hospital affiliated to Shanghai University of Traditional Chinese Medicine, No.528 Zhangheng Road, Pudong New Area, Shanghai 201203, China. email@example.com
Telephone: +86-21-20256526 Fax: +86-21-20256521
Received: May 4, 2018
Peer-review started: May 4, 2018
First decision: May 23, 2018
Revised: June 8, 2018
Accepted: June 25, 2018
Article in press: June 25, 2018
Published online: August 14, 2018