Novel sericin-based hepatocyte serum-free medium and sericin’s effect on hepatocyte transcriptome
Yun Huang, Qing Peng, Hai-Yan Li, Zhi-Dong Jia, Yang Li, Yi Gao, Department of Hepatobiliary Surgery II, Guangdong Provincial Research Center for Artificial Organ and Tissue Engineering, Guangzhou Clinical Research and Transformation Center for Artificial Liver, Institute of Regenerative Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, Guangdong Province, China
Yi Gao, State Key Laboratory of Organ Failure Research, Southern Medical University, Guangzhou 510515, Guangdong Province, China
Author contributions: Huang Y performed the whole process of this study, including the concept, study design, operation of the experiments, data analysis, statistics and article drafting; Peng Q assisted with study design and critical revision of the article; Li HY, Jia ZD and Li Y assisted with the operation of the experiments; Gao Y laid out the concept and performed the critical revision and final approval of the article.
Supported by the National Natural Science Foundation of China, No. 81470875; the Natural Science Foundation of Guangdong Province, No. 2014A030312013; Science and Technology Planning Project of Guangdong Province, No. 2014B020227002, No. 2015B090903069, and No. 2015B020229002; and Science and Technology Program of Guangzhou, No. 201604020002.
Conflict-of-interest statement: All authors declare no conflicts-of-interest related to this article.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Yi Gao, MD, PhD, Chief Doctor, Professor, Surgeon, Department of Hepatobiliary Surgery II, Guangdong Provincial Research Center for Artificial Organ and Tissue Engineering, Guangzhou Clinical Research and Transformation Center for Artificial Liver, Institute of Regenerative Medicine, Zhujiang Hospital of Southern Medical University, 253 Middle Industrial Avenue, Guangzhou 510515, Guangdong Province, China. firstname.lastname@example.org
Telephone: +86-18922345399 Fax: +86-20-61643207
Received: May 11, 2018
Peer-review started: May 11, 2018
First decision: June 11, 2018
Revised: June 17, 2018
Accepted: June 28, 2018
Article in press: June 28, 2018
Published online: August 14, 2018