Akcay IM, Katrinli S, Ozdil K, Doganay GD, Doganay L. Host genetic factors affecting hepatitis B infection outcomes: Insights from genome-wide association studies. World J Gastroenterol 2018; 24(30): 3347-3360 [PMID: 30122875 DOI: 10.3748/wjg.v24.i30.3347]
Corresponding Author of This Article
Levent Doganay, MD, Associate Professor, Doctor, Department of Gastroenterology and Hepatology, Umraniye Teaching and Research Hospital, Umraniye, Istanbul 34764, Turkey. levent.doganay@saglik.gov.tr
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Izzet Mehmet Akcay, Seyma Katrinli, Gizem Dinler Doganay, Department of Molecular Biology and Genetics, Istanbul Technical University, Istanbul 34469, Turkey
Kamil Ozdil, Levent Doganay, Department of Gastroenterology and Hepatology, Umraniye Teaching and Research Hospital, Istanbul 34764, Turkey
Author contributions: Akcay IM and Katrinli S researched the literature and wrote the article; Akcay IM, Katrinli S, Ozdil K, Doganay GD and Doganay L discussed the content; Akcay IM, Katrinli S, Doganay GD and Doganay L reviewed and edited the manuscript before submission; all authors approved the final version of the manuscript to be published.
Conflict-of-interest statement: We declare no potential conflict of interests.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Levent Doganay, MD, Associate Professor, Doctor, Department of Gastroenterology and Hepatology, Umraniye Teaching and Research Hospital, Umraniye, Istanbul 34764, Turkey. levent.doganay@saglik.gov.tr
Received: April 9, 2018 Peer-review started: April 10, 2018 First decision: May 16, 2018 Revised: May 29, 2018 Accepted: June 25, 2018 Article in press: June 25, 2018 Published online: August 14, 2018
Core Tip
Core tip: Genome-wide association studies (GWAS) have proven to be very useful in uncovering the host genetic factors that influence the clinical outcomes of hepatitis B virus (HBV) infection. Both class I and class II human leukocyte antigen (HLA) genes were implicated in persistence of HBV infection; associated variants affected antigen-binding specificities and expression levels of HLA molecules. HBV persistence and vaccine nonresponse were associated with the same HLA-DP allotypes, suggesting a critical role for the surface antigen in HBV pathogenesis. These findings might be exploited for development of potent vaccines based on alternative epitopes. GWAS for HBV-related pathologies identified many other immune-related genes, and provided genetic markers to detect the individuals at high risk for HBV-related diseases.
