Copyright ©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 7, 2018; 24(29): 3239-3249
Published online Aug 7, 2018. doi: 10.3748/wjg.v24.i29.3239
Rethinking de novo immune hepatitis, an old concept for liver allograft rejection: Relevance of glutathione S-transferase T1 mismatch
Isabel Aguilera, Elena Aguado-Dominguez, Jose Manuel Sousa, Antonio Nuñez-Roldan
Isabel Aguilera, Elena Aguado-Dominguez, Antonio Nuñez-Roldan, Department of Immunology, Instituto de Biomedicina de Sevilla (IBIS), Hospital Universitario Virgen del Rocío, Sevilla 41013, Spain
Jose Manuel Sousa, Digestive and Liver Diseases Service, Hospital Universitario Virgen del Rocío, Sevilla 41013, Spain
Author contributions: Aguilera I contributed to this paper with the conception, literature review and drafting; Aguado-Dominguez E contributed with literature review, original data and drafting; Sousa JM and Nuñez-Roldan A contributed with critical revision of the manuscript and approval of the final version.
Supported by Andalusian Government, Proyecto de Excelencia, No. CTS-7846; and Spanish Ministry of Economy, Instituto de Salud Carlos III, No. 11/857 and No. 17/1403.
Conflict-of-interest statement: No potential conflicts of interest. No financial support.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Isabel Aguilera, PhD, Research Fellow, Senior Scientist, Department of Immunology, Instituto de Biomedicina de Sevilla (IBIS), Hospital Universitario Virgen del Rocío, Avda Manuel Siurot s/n, Sevilla 41013, Spain.
Telephone: +34-955923120
Received: May 3, 2018
Peer-review started: May 4, 2018
First decision: May 17, 2018
Revised: June 28, 2018
Accepted: June 30, 2018
Article in press: June 30, 2018
Published online: August 7, 2018
Core Tip

Core tip: The purpose of this review is to update the reader with recent knowledge about a disease of the liver allograft, whose definition has evolved from “de novo autoimmune hepatitis” to “plasma cell-rich rejection”. During the last 20 years, several groups have contributed new data that has prompted the liver transplant community to reconsider several aspects of the disease. It is not the intention of this review to go over details of the histological features or the role of autoantibodies in this disease, which have been well described in other reviews. Instead, more recent aspects, such as the composition of infiltrates in biopsies and T cell involvement will be discussed.