Total polysaccharides of the Sijunzi decoction attenuate tumor necrosis factor-α-induced damage to the barrier function of a Caco-2 cell monolayer via the nuclear factor-κB-myosin light chain kinase-myosin light chain pathway
Yue Lu, Leng Li, Jin-Wei Zhang, Xiao-Qin Zhong, Jian-An Wei, Ling Han, The Second Clinical College (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong Province, China
Author contributions: Han L conceived and designed research; Lu Y, Li L and Zhang JW performed research; Lu Y and Zhong XQ analyzed data; Lu Y wrote the manuscript; Wei JA and Han L approved and reviewed the final manuscript; all authors have read and agreed with the final manuscript.
Supported by the National Natural Science Foundation of China, No. 81202635; and the Guangdong Provincial Bureau of Chinese Medicine, No. 20151244.
Institutional review board statement: This study was reviewed and approved by the review board of the Second Clinical College affiliated with Guangzhou University of Chinese Medicine.
Conflict-of-interest statement: All authors declare that there are no competing interests.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Ling Han, PhD, Research Scientist, The Second Clinical College, Guangzhou University of Chinese Medicine, Inner Ring Western Road, University Town, Guangzhou 510006, Guangdong Province, China. firstname.lastname@example.org
Telephone: +86-20-39318678 Fax: +86-20-39318678
Received: March 29, 2018
Peer-review started: March 30, 2018
First decision: May 17, 2018
Revised: May 25, 2018
Accepted: June 9, 2018
Article in press: June 9, 2018
Published online: July 14, 2018