Published online Jun 28, 2018. doi: 10.3748/wjg.v24.i24.2555
Peer-review started: March 27, 2018
First decision: April 19, 2018
Revised: May 10, 2018
Accepted: June 2, 2018
Article in press: June 2, 2018
Published online: June 28, 2018
Core tip: There are more than 11 million hepatitis C virus (HCV)-infected children worldwide. Most new HCV-infected cases have occurred through vertical transmission. Currently, a new era of highly effective direct-acting antiviral agents for the treatment of HCV infection has begun for paediatric patients. The first results of clinical trials with interferon-free therapy are very promising. ESPGHAN developed a position paper for the management of chronic HCV infection in children. Non-invasive methods to measure hepatic fibrosis enable the identification of patients with significant liver fibrosis. This article summarizes the current data on epidemiology, new therapies and non-invasive methods in paediatric patients with HCV infection.