Ischemia/reperfusion injury in porcine intestine - Viability assessment
Runar J Strand-Amundsen, Jan O Høgetveit, Department of Clinical and Biomedical Engineering, Oslo University Hospital, Oslo 0424, Norway
Runar J Strand-Amundsen, Jan O Høgetveit, Department of Physics, University of Oslo, Oslo 0316, Norway
Henrik M Reims, Finn P Reinholt, Department of Pathology, Oslo University Hospital, Oslo 0424, Norway
Tom E Ruud, Institute for Surgical Research, Oslo University Hospital, Oslo 0424, Norway
Tom E Ruud, Department of Surgery, Baerum Hospital, Vestre Viken Hospital Trust, Drammen 3004, Norway
Runkuan Yang, Tor I Tønnessen, Department of Emergencies and Critical Care, Oslo University Hospital, Oslo 0424, Norway
Tor I Tønnessen, Institute of Clinical Medicine, University of Oslo, Oslo 0424, Norway
Author contributions: Strand-Amundsen RJ, Yang R and Tønnessen TI performed the experiments, collected the histological samples and analyzed the microdialysis data; Reims HM and Reinholt FP analyzed, described and graded the histological samples; Strand-Amundsen RJ, Tønnessen TI, Ruud TE and Høgetveit JO designed and coordinated the research; Strand-Amundsen RJ wrote the paper with assistance and input from all the co-authors.
Supported by the Norwegian Research Council through the Integrisc project number 219819, and by Sensocure AS, Langmyra 11, 3185 Skoppum, Norway.
Institutional review board statement: The study was reviewed and approved by the Research and Development section at the Department of Clinical and Biomedical Engineering at the Oslo University Hospital.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Animal Ethics and Welfare Committee of Oslo University Hospital, and the Norwegian Food Authority (FOTS ID 8304 and 12695). The experiment was conducted in accordance with Norwegian animal welfare guidelines (FOR-2015-06-18-761) and EU directive (2010/63/EU).
Conflict-of-interest statement: The authors declare that they have no competing interests.
Data sharing statement: Readers can request the data of this paper by contacting us via firstname.lastname@example.org.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Runar J Strand-Amundsen, MSc, Research Scientist, Department of Physics, University of Oslo, Postboks 1048 Blindern, Oslo 0316, Norway. email@example.com
Received: March 9, 2018
Peer-review started: March 10, 2018
First decision: April 11, 2018
Revised: April 20, 2018
Accepted: April 23, 2018
Article in press: April 23, 2018
Published online: May 14, 2018