Maintenance for healed erosive esophagitis: Phase III comparison of vonoprazan with lansoprazole
Kiyoshi Ashida, Department of Gastroenterology, Rakuwakai Otowa Hospital, Kyoto 607-8062, Japan
Katsuhiko Iwakiri, Department of Gastroenterology, Nippon Medical School Graduate School of Medicine, Tokyo 113-8603, Japan
Naoki Hiramatsu, Department of Gastroenterology and Hepatology, Osaka Rosai Hospital, Sakai, Osaka 591-8025, Japan
Yuuichi Sakurai, Tetsuharu Hori, Kentarou Kudou, Akira Nishimura, Takeda Pharmaceutical Company Limited, Osaka 540-8645, Japan
Eiji Umegaki, Department of Gastroenterology, Kobe University Graduate School of Medicine, Kobe, Hyogo 650-0017, Japan
Author contributions: Ashida K, Sakurai Y, Hori T and Nishimura A were involved in study conception and design; Hiramatsu N served as Medical Expert; Umegaki E, Iwakiri K and Ashida K served as the Central Adjudication Committee; Kudou K conducted statistical analyses; all authors were involved in the drafting and critical revision of the manuscript, and approved the final version, including the authorship list.
Institutional review board statement: The study was reviewed and approved by the institutional review board of each participating site.
Clinical trial registration statement: This study is registered at ClinicalTrials.gov. The registration identification number is NCT01459367.
Informed consent statement: All study participants provided written informed consent prior to study enrollment.
Conflict-of-interest statement: Kiyoshi Ashida has received fees and honoraria from Takeda Pharmaceutical Company Limited and Otsuka Pharmaceutical Company Limited; Katsuhiko Iwakiri has received grants, fees, and honoraria from Takeda Pharmaceutical Company Limited, and fees from Otsuka Pharmaceutical Company Limited; Yuuichi Sakurai, Tetsuharu Hori, Kentarou Kudou, and Akira Nishimura are full-time employees of Takeda Pharmaceutical Company Limited; Naoki Hiramatsu and Eiji Umegaki have no conflicts of interest to declare.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Kiyoshi Ashida, MD, PhD, Department of Gastroenterology, Rakuwakai Otowa Hospital, 2 Otowachinji-cho, Yamashina-ku, Kyoto 607-8062, Japan. firstname.lastname@example.org
Telephone: +81-75-5934111 Fax: +81-75-5934160
Received: November 30, 2017
Peer-review started: December 1, 2017
First decision: December 13, 2017
Revised: February 6, 2018
Accepted: March 7, 2018
Article in press: March 6, 2018
Published online: April 14, 2018