Copyright
©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 28, 2018; 24(12): 1332-1342
Published online Mar 28, 2018. doi: 10.3748/wjg.v24.i12.1332
Published online Mar 28, 2018. doi: 10.3748/wjg.v24.i12.1332
Intraoperative frozen section diagnosis of bile duct margin for extrahepatic cholangiocarcinoma
Takayuki Shiraki, Keiichi Kubota, Department of Gastroenterological Surgery, Dokkyo Medical University, Tochigi 321-0293, Japan
Hajime Kuroda, Atsuko Takada, Yoshimasa Nakazato, Yasuo Imai, Department of Diagnostic Pathology, Dokkyo Medical University, Tochigi 321-0293, Japan
Author contributions: Shiraki T and Kuroda H contributed equally to this work; Shiraki T collected clinical information; Kuroda H and Imai Y reviewed the pathological diagnosis; Shiraki T, Kuroda H, and Imai Y analyzed the data and wrote the manuscript; Takada A and Nakazato Y made critical revisions of the manuscript; Kubota K and Imai Y designed the study; Imai Y gave the final approval of the manuscript for publication.
Supported by JSPS KAKENHI (No. JP16K08695) from the Ministry of Education, Culture, Sports, Science and Technology of Japan.
Institutional review board statement: This study protocol was approved by the ethical review board in the Dokkyo Medical University Hospital (DMUH: R-2-21).
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: The authors declare no competing interests related to this study.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Yasuo Imai, MD, PhD, Department of Diagnostic Pathology, Dokkyo Medical University, 880 Kitakobayashi, Mibu, Shimotsuga, Tochigi 321-0293, Japan. ya-imai@dokkyomed.ac.jp
Telephone: +81-282-872130 Fax: +81-282-861681
Received: February 13, 2018
Peer-review started: February 13, 2018
First decision: February 24, 2018
Revised: March 5, 2018
Accepted: March 7, 2018
Article in press: March 7, 2018
Published online: March 28, 2018
Peer-review started: February 13, 2018
First decision: February 24, 2018
Revised: March 5, 2018
Accepted: March 7, 2018
Article in press: March 7, 2018
Published online: March 28, 2018
Core Tip
Core tip: Usefulness of intraoperative frozen section diagnosis (FSD) of bile duct margin for extrahepatic cholangiocarcinoma was investigated. The diagnosis was classified into negative, borderline (biliary intraepithelial neoplasia-1 and 2, and indefinite for neoplasia), or positive, and FSD was compared with permanent section diagnosis postoperatively. In contrast to previous studies, positive FSD in the epithelial layer was significantly associated with local recurrence. Furthermore, borderline FSD in the epithelial layer could be substantially regarded as negative, which could aid surgeons to determine the resection range of the bile duct. Finally, we demonstrated that FSD was reliable enough for pathological diagnosis.