Do pathological variables have prognostic significance in rectal adenocarcinoma treated with neoadjuvant chemoradiotherapy and surgery?
Luca Reggiani Bonetti, Federica Domati, Department of Laboratory Integrated Activities, Anatomic Pathology and Legal Medicine, Section of Pathology, University of Modena and Reggio Emilia, 41124 Modena, Italy
Simona Lionti, Valeria Barresi, Department of Pathology in Evolutive Age and Adulthood, “Gaetano Barresi”, University of Messina, 98125 Messina, Italy
Author contributions: Reggiani Bonetti L designed the study, revised the histological slides, analyzed the results and wrote the paper; Lionti S designed the study, performed the statistical analyses and supervised the report; Domati F designed the study, collected the clinical data and supervised the report; Barresi V designed the study, revised the histological slides, analyzed the results and supervised the report.
Institutional review board statement: Ethical issues were discussed with the local ethics committee. Since the study was retrospective, no approval was needed to revise the histological slides.
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: We have no financial relationships to disclose.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Valeria Barresi, Department of Pathology in Evolutive Age and Adulthood, “Gaetano Barresi”, University of Messina, Via Consolare Valeria, 98125 Messina, Italy. email@example.com
Received: October 22, 2016
Peer-review started: October 25, 2016
First decision: December 19, 2016
Revised: December 29, 2016
Accepted: January 17, 2017
Article in press: January 17, 2017
Published online: February 28, 2017