Retrospective Cohort Study
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 28, 2017; 23(8): 1397-1405
Published online Feb 28, 2017. doi: 10.3748/wjg.v23.i8.1397
Impact of smoking habit on surgical outcomes in non-B non-C patients with curative resection for hepatocellular carcinoma
Keita Kai, Hiroki Koga, Shinichi Aishima, Atsushi Kawaguchi, Koutaro Yamaji, Takao Ide, Junji Ueda, Hirokazu Noshiro
Keita Kai, Shinichi Aishima, Department of Pathology, Saga University Hospital, Saga 849-8501, Japan
Hiroki Koga, Koutaro Yamaji, Takao Ide, Junji Ueda, Hirokazu Noshiro, Departments of Surgery, Saga University Hospital, Saga 849-8501, Japan
Shinichi Aishima, Koutaro Yamaji, Pathology and Microbiology, Saga University Hospital, Saga 849-8501, Japan
Atsushi Kawaguchi, Center for Comprehensive Community Medicine, Saga University Faculty of Medicine, Saga 849-8501, Japan
Author contributions: Kai K the main author of this article, designed the study, conducted the data collection, and contributed to the statistical analyses; Koga H contributed to the data correction and statistical analyses; Aishima S performed the pathological work and reviewed the manuscript; Kawaguchi A supervised the statistical analyses; Yamaji K, Ide T and Ueda J contributed to the data collection; Noshiro H contributed to the data collection and reviewed the manuscript; all authors have read and approved the final manuscript.
Institutional review board statement: The protocol of this study was reviewed and approved by the Ethics Committee of the Faculty of Medicine at Saga University.
Informed consent statement: Informed consent for the use of resected tissue and medical information was obtained from all patients.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest.
Data sharing statement: The clinical dataset is available from the corresponding author at email: Participant consent for data sharing was not obtained, but the presented data are anonymized and the risk of identification is low.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Dr. Keita Kai, MD, Department of Pathology, Saga University Hospital, Nabeshima 5-1-1, Saga City, Saga 849-8501, Japan.
Telephone: +81-952-343264 Fax: +81-952-342055
Received: November 27, 2016
Peer-review started: November 28, 2016
First decision: December 19, 2016
Revised: December 31, 2016
Accepted: January 11, 2017
Article in press: January 11, 2017
Published online: February 28, 2017
Core Tip

Core tip: We retrospectively analyzed the surgical outcomes and clinicopathological characteristics according to smoking habits in consecutive 83 cases with non-B non-C hepatocellular carcinoma (NBNC-HCC) patients who underwent curative surgical treatment for the primary lesion. Current smoking status was strongly correlated with both overall survival and disease-specific survival by multivariate analyses. Subset analyses revealed that current smokers tended to have multiple HCCs at a younger age than other patients. To our knowledge, this is the first report regarding surgical outcomes of NBNC-HCC patients in relation to their smoking status.