Pharmacokinetics and pharmacodynamics of Da-Cheng-Qi decoction in the liver of rats with severe acute pancreatitis
Yu-Mei Zhang, Hong-Yu Ren, Juan Li, Jun-Yi Li, Wen-Fu Tang, Sichuan Provincial Pancreatitis Center, Department of Integrative Medicine, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Fu-Sheng Wu, Hang Su, School of Acupuncture, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan Province, China
Xian-Lin Zhao, Department of Integrative Medicine, Chengdu Integrated TCM and Western Medicine Hospital, Chengdu 610016, Sichuan Province, China
Author contributions: Zhang YM and Ren HY contributed equally to this work; Tang WF designed the research; Zhang YM, Ren HY, Zhao XL, Li J and Su H performed this study; Zhao XL, Li JY and Wu FS analyzed the data; Zhang YM and Ren HY wrote the paper; Tang WF was responsible for the critical revision of the paper.
Supported by National Natural Science Foundation of China, No. 81374042, No. 81370091 and No. 81573857.
Institutional review board statement: This study was approved by the Animal Ethics Committee of the Animal Facility of the West China Hospital (Chengdu, China).
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Animal Ethics Committee of the Animal Facility of the West China Hospital (protocol number: 2016001A, Chengdu, China) according to the Guide for the Care and Use of Laboratory Animals of Sichuan University.
Conflict-of-interest statement: The authors declared that they have no conflicts of interest to this work.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Wen-Fu Tang, Professor, Sichuan Provincial Pancreatitis Center, Department of Integrative Medicine, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang, Chengdu 610041, Sichuan Province, China. firstname.lastname@example.org
Telephone: +86-28-85423546 Fax: +86-28-85423373
Received: October 5, 2016
Peer-review started: October 6, 2016
First decision: October 20, 2016
Revised: November 6, 2016
Accepted: January 11, 2017
Article in press: January 11, 2017
Published online: February 28, 2017