Published online Feb 28, 2017. doi: 10.3748/wjg.v23.i8.1325
Peer-review started: October 25, 2016
First decision: December 2, 2016
Revised: December 5, 2016
Accepted: December 21, 2016
Article in press: December 21, 2016
Published online: February 28, 2017
Core tip: Although several mechanisms for the favorable effects of vitamin D3 (VitD3) supplementation were reported, the total effect of VitD3 supplementation remains unclear. Recently, the main treatment of chronic hepatitis C should be direct acting antivirals (DAAs) without pegylated interferon (Peg-IFN). Peg-IFN is a strong immune-modulator. Therefore, an immunological analysis should be carried out to understand the effect of VitD3 after treatment of DAAs without Peg-IFN. The induction of a favorable immune response by adding VitD3 might be able to suppress the hepatocarcinogenesis after achieving SVR, especially in children and elderly patients with severe fibrosis lacking sufficient amounts of VitD3.