Basic Study
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 21, 2017; 23(7): 1203-1214
Published online Feb 21, 2017. doi: 10.3748/wjg.v23.i7.1203
Caffeic acid phenethyl ester up-regulates antioxidant levels in hepatic stellate cell line T6 via an Nrf2-mediated mitogen activated protein kinases pathway
Ning Yang, Juan-Juan Shi, Feng-Ping Wu, Mei Li, Xin Zhang, Ya-Ping Li, Song Zhai, Xiao-Li Jia, Shuang-Suo Dang
Ning Yang, Juan-Juan Shi, Feng-Ping Wu, Mei Li, Xin Zhang, Ya-Ping Li, Song Zhai, Xiao-Li Jia, Shuang-Suo Dang, Department of Infectious Diseases, the Second Affiliated Hospital of Medical School of Xi’an Jiaotong University, Xi’an 710004, Shannxi Province, China
Author contributions: Yang N and Dang SS designed the research; Yang N, Shi JJ, Wu FP, Li M, Zhang X and Li YP performed the research; Yang N, Zhai S and Jia XL analyzed the data; and Yang N and Shi JJ wrote the paper.
Supported by the Liver Fibrosis Foundation of Wang Bao-En of China, No. 20100033; and the Science and Technology Foundation of Shaanxi Province of China, No. 2010K01-199.
Institutional review board statement: No human or animal subjects were used in this study.
Conflict-of-interest statement: To the best of our knowledge, no conflict of interest exists.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Shuang-Suo Dang, PhD, MD, Department of Infectious Diseases, the Second Affiliated Hospital of Medical School of Xi’an Jiaotong University, No. 157 Xi’wu Road, Xi’an 710004, Shaanxi Province, China. dang212@126.com
Telephone: +86-29-87679688 Fax: +86-29-87679688
Received: November 15, 2016
Peer-review started: November 15, 2016
First decision: December 19, 2016
Revised: December 27, 2016
Accepted: January 11, 2017
Article in press: January 11, 2017
Published online: February 21, 2017
Core Tip

Core tip: Liver fibrosis is a pathological response to hepatocyte injury, including oxidative stress, which is a primary mechanism of liver damage. Caffeic acid phenethyl ester (CAPE) is a phenolic compound extracted from honeybee propolis that has strong biological properties in liver protection and as an antioxidant and anti-fibrosis agent. It has been used in the treatment of several diseases. In this study, we investigated the antioxidant effect of CAPE in HSC-T6 cells and its potential mechanism. Our results demonstrated that CAPE inhibited cell proliferation and up-regulated the antioxidant levels in HSC-T6 cells partly through the Nrf2-MAPKs signaling pathway.