Melatonin, a novel selective ATF-6 inhibitor, induces human hepatoma cell apoptosis through COX-2 downregulation
Li-Jia Bu, Han-Qing Yu, Lu-Lu Fan, Xiao-Qiu Li, Fang Wang, Jia-Tao Liu, Fei Zhong, Cong-Jun Zhang, Hua Wang, Guo-Ping Sun, Department of Oncology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China
Jia-Tao Liu, Department of Pharmacy, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China
Wei Wei, Institute of Clinical Pharmacology, Anhui Medical University, Hefei 230032, Anhui Province, China
Hua Wang, Institute for Liver Diseases of Anhui Medical University, Hefei 230032, Anhui Province, China
Author contributions: Bu LJ, Yu HQ and Fan LL contributed equally to this work; Bu LJ, Yu HQ and Fan LL performed select experiments and analyzed data; Li XQ and Wang F performed select experiments; Liu JT and Zhong F performed select histopathological experiments; Zhang CJ and Wei W read the manuscript and gave important intellectual suggestions; Wang H and Sun GP prepared the manuscript, and designed and supervised the project.
Supported by grants from the National Natural Science Foundation of China, No. 81572430 and No. 81272739.
Institutional review board statement: The study was carried out in accordance with a protocol approved by the Ethics Committee of Anhui Medical University (Anhui, China).
Conflict-of-interest statement: No conflicts of interest exist for any of the authors.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Guo-Ping Sun, Department of Oncology, the First Affiliated Hospital of Anhui Medical University, No. 218 Jixi Road, Hefei 230022, Anhui Province, China. email@example.com
Telephone: +86-551-62923509 Fax: +86-551-62923509
Received: August 31, 2016
Peer-review started: August 31, 2016
First decision: September 28, 2016
Revised: October 11, 2016
Accepted: October 27, 2016
Article in press: October 27, 2016
Published online: February 14, 2017