Copyright
©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Dec 7, 2017; 23(45): 8053-8061
Published online Dec 7, 2017. doi: 10.3748/wjg.v23.i45.8053
Published online Dec 7, 2017. doi: 10.3748/wjg.v23.i45.8053
Gender differences in ghrelin, nociception genes, psychological factors and quality of life in functional dyspepsia
Yoon Jin Choi, Young Soo Park, Nayoung Kim, Sun Min Lee, Dong Ho Lee, Department of Internal Medicine, Seoul National University Bundang Hospital, Seoungnam, Gyeonggi-do 13620, South Korea
Nayoung Kim, Dong Ho Lee, Hyun Chae Jung, Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, 03080, South Korea
Yong Sung Kim, Department of Gastroenterology, Wonkwang Digestive Disease Research Institute, Wonkwang University Sanbon Hospital, Gunpo, Gyeonggi-do 1142, South Korea
Author contributions: Choi YJ and Park YS equally contributed to this manuscript; Choi YJ and Park YS analyzed data and drafted the article; Kim N designed this study, collected the data and supervised the writing of the this manuscript; Kim YS and Lee SM edited the manuscript; Lee DH and Jung HC provided advice on the study design and supervised the writing of the manuscript; all authors have read and approved the final draft of this paper.
Supported by Support Program for Women in Science, Engineering and Technology through the National Research Foundation of Korea funded by the Ministry of Science, ICT and Future Planning, no. 2016H1C3A1903202.
Institutional review board statement: The Institutional Review Board of SNUBH approved this study (B-1101/119-010).
Informed consent statement: Written informed consent was obtained from all participants.
Conflict-of-interest statement: All authors declare that they have no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Nayoung Kim, MD, Department of Internal Medicine, Seoul National University Bundang Hospital, 82, Gumi-ro 173beon-gil, Bundang-gu, Seongnam, Gyeonggi-do 13620, South Korea. nayoungkim49@empas.com
Telephone: +82-31-7877008 Fax: +82-31-7874051
Received: August 3, 2017
Peer-review started: August 5, 2017
First decision: September 13, 2017
Revised: September 27, 2017
Accepted: November 8, 2017
Article in press: November 8, 2017
Published online: December 7, 2017
Peer-review started: August 5, 2017
First decision: September 13, 2017
Revised: September 27, 2017
Accepted: November 8, 2017
Article in press: November 8, 2017
Published online: December 7, 2017
Core Tip
Core tip: Gender-specific medicine has become a recently rising medical field in which differences between males and females are recognized and actively utilized in the clinical study, diagnosis and treatment. The lower level of plasma acyl ghrelin and higher expressions of nociception-related genes are associated with pathogenesis of functional dyspepsia (FD) in males, while female FD patients had more serious anxious and depressive mood. Underlying mechanism in FD could be different according to gender, and meticulous attention for psychological predisposition is required particularly in the treatment of female FD patients.