Published online Nov 21, 2017. doi: 10.3748/wjg.v23.i43.7666
Peer-review started: July 24, 2017
First decision: August 28, 2017
Revised: September 13, 2017
Accepted: September 28, 2017
Article in press: September 28, 2017
Published online: November 21, 2017
Core tip: Liver sinusoidal endothelial cells (LSECs) comprise the highest proportion of nonparenchymal cells in the liver. Their fenestrae and basement membrane structure, and high endocytic clearance ability play an indispensable role in the physiology and pathology of the liver. LSECs mainly participate in the regulation of liver pathology, such as hepatitis, liver fibrosis, cirrhosis and liver regeneration, by exerting anti-inflammatory activity, endocytosis, secretion, synthesis of angiogenesis signaling molecules and maintaining the hepatic stellate cell phenotype. It is important to elucidate the mechanism of action of LSECs, which will provide important information for future targeted therapy and clinical diagnosis.