Basic Study
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Nov 14, 2017; 23(42): 7563-7571
Published online Nov 14, 2017. doi: 10.3748/wjg.v23.i42.7563
Effects of Hemp seed soft capsule on colonic ion transport in rats
Xiao-Fang Lu, Meng-Di Jia, Sheng-Sheng Zhang, Lu-Qing Zhao
Xiao-Fang Lu, Meng-Di Jia, Sheng-Sheng Zhang, Lu-Qing Zhao, Digestive Disease Center, Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University, Beijing 100010, China
Author contributions: Lu XF, Zhang SS and Zhao LQ designed the study; Lu XF and Jia MD performed the majority of experiments, analyzed the data and wrote the article; Lu XF and Jia MD contributed equally to this work; All the authors approved the final version of the article to be published.
Supported by the Clinical Medicine Development Project of Beijing Municipal Administration of Hospitals, No. ZYLX201411.
Institutional review board statement: The study was reviewed and approved by the Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University Review Board.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Institute of Basic Theory, China Academy of Chinese Medical Sciences Ethics Committee (No. 20160905).
Conflict-of-interest statement: None of the authors declared any conflicts of interest related to this study.
Data sharing statement: No additional data were available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Sheng-Sheng Zhang, MD, Digestive Disease Center, Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University, 23 Meishuguanhou Street, Beijing 100010, China. zhss2000@163.com
Telephone: +86-10-52176634 Fax: +86-10-52176634
Received: July 2, 2017
Peer-review started: July 20, 217
First decision: August 21, 2017
Revised: September 8, 2017
Accepted: September 19, 2017
Article in press: September 19, 2017
Published online: November 14, 2017
Core Tip

Core tip: In this study, we established a constipation model using the application of loperamide and found that Hemp seed soft capsule could improve the symptom of constipation. Further, it was found that the effect of Hemp seed soft capsule might be achieved by increasing colonic secretion, which is mediated via the combined action of cAMP-dependent and Ca2+-dependent Cl- channels, Na+-K+-2Cl- cotransporter, Na+-HCO3- cotransporter or Cl-/HCO3- exchanger. However, the submucosal neurons seemed to not play a key role in the process.