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©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Nov 7, 2017; 23(41): 7425-7432
Published online Nov 7, 2017. doi: 10.3748/wjg.v23.i41.7425
Published online Nov 7, 2017. doi: 10.3748/wjg.v23.i41.7425
Value of gamma-glutamyltranspeptidase-to-platelet ratio in diagnosis of hepatic fibrosis in patients with chronic hepatitis B
Yan-Chao Hu, Xiao-Yan Liu, Li-Na Ma, Yu-Hua Guan, Xia Luo, Xiang-Chun Ding, Department of Infectious Diseases, General Hospital of Ningxia Medical University, Yinchuan 750001, Ningxia Hui Autonomous Region, China
Hao Liu, Department of Gastroenterology, General Hospital of Ningxia Medical University, Yinchuan 750001, Ningxia Hui Autonomous Region, China
Author contributions: Hu YC, Liu H, Liu XY, Ma LN, Guan YH, and Ding XC performed the study; Hu YC, Liu H, and Luo X collected and analyzed the data; and Hu YC designed the study and wrote the manuscript.
Supported by National Natural Science Foundation of China, No. 81460301 and No. 81760363; Key Project of Natural Science Foundation of Ningxia, No. NZ15134.
Conflict-of-interest statement: The authors declare that there are no conflicts of interest related to this study.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Xiang-Chun Ding, Department of Infectious Disease, General Hospital of Ningxia Medical University, 804 Shengli Street, Yinchuan 750004, Ningxia Hui Autonomous Region, China. dingxiangchun@nyfy.com.cn
Telephone: +86-136-19511768
Received: August 5, 2017
Peer-review started: August 7, 2017
First decision: September 4, 2017
Revised: September 14, 2017
Accepted: September 29, 2017
Article in press: September 28, 2017
Published online: November 7, 2017
Peer-review started: August 7, 2017
First decision: September 4, 2017
Revised: September 14, 2017
Accepted: September 29, 2017
Article in press: September 28, 2017
Published online: November 7, 2017
Core Tip
Core tip: Hepatic fibrosis is a precursor of cirrhosis for chronic hepatitis B patients. Severe hepatic fibrosis and cirrhosis can increase the incidence and mortality of primary liver cancer. Although liver biopsy is still the gold standard for the diagnosis of liver fibrosis, it is not widely used as a routine examination because of its invasiveness, high cost, and lack of repeatability. Identification of a simple, convenient, cheap, and noninvasive index to assess patients’ hepatic fibrosis level is thus urgently needed. The aim of the present study was to investigate the value of the gamma-glutamyltranspeptidase-to-platelet ratio in the diagnosis of hepatic fibrosis in patients with chronic hepatitis B.