Retrospective Study
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jan 28, 2017; 23(4): 676-686
Published online Jan 28, 2017. doi: 10.3748/wjg.v23.i4.676
Negative oncologic impact of poor postoperative pain control in left-sided pancreatic cancer
Eun-Ki Min, Jae Uk Chong, Ho Kyoung Hwang, Sang Joon Pae, Chang Moo Kang, Woo Jung Lee
Eun-Ki Min, Yonsei University College of Medicine, Seoul 03722, South Korea
Jae Uk Chong, Ho Kyoung Hwang, Chang Moo Kang, Woo Jung Lee, Department of Hepatobiliary and Pancreatic Surgery, Yonsei University College of Medicine, Seoul 03722, South Korea
Jae Uk Chong, Ho Kyoung Hwang, Chang Moo Kang, Woo Jung Lee, Pancreaticobiliary Cancer Clinic, Yonsei Cancer Center, Severance Hospital, Seoul 03722, South Korea
Sang Joon Pae, National Health Insurance Corporation Ilsan Hospital, Goyang 10444, South Korea
Author contributions: Min EK, Chong JU and Hwang HK performed the research, analyzed the data, and wrote the paper; Pae SJ contributed to the analysis and provided clinical advice; Kang CM and Lee WJ designed the research and supervised the report.
Institutional review board statement: The study was reviewed and approved by the Institutional Review Board of Yonsei University College of Medicine, Seoul 03722, South Korea.
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent. Individuals can’t be identified according to the data presented.
Conflict-of-interest statement: All authors have no financial relationships to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Chang Moo Kang, MD, PhD, Associate Professor, Department of Hepatobiliary and Pancreatic Surgery, Yonsei University College of Medicine, 50 Yonsei-Ro, Seodaemun-Ku, Seoul 03722, South Korea. cmkang@yuhs.ac
Telephone: +82-2-22282120 Fax: +82-2-3138289
Received: October 4, 2016
Peer-review started: October 8, 2016
First decision: October 28, 2016
Revised: November 14, 2016
Accepted: January 2, 2017
Article in press: January 3, 2017
Published online: January 28, 2017
Core Tip

Core tip: This is a retrospective review to evaluate the association between postoperative pain control and oncologic outcomes in resected pancreatic ductal adenocarcinoma. In multivariate analysis, poor patients’ perceived pain control was an independent risk factor for both disease-free survival (HR = 4.157; 95%CI: 1.938-8.915; P < 0.001) and overall survival (HR = 4.741; 95%CI: 2.214-10.153; P < 0.001) in resected left-sided pancreatic cancer. Adequate postoperative pain control to reduce patients’ perceived pain during immediate postoperative period may be as important as adjuvant therapy in resected left-sided pancreatic cancer.