Basic Study
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jan 28, 2017; 23(4): 603-613
Published online Jan 28, 2017. doi: 10.3748/wjg.v23.i4.603
Suppression of colorectal tumorigenesis by recombinant Bacteroides fragilis enterotoxin-2 in vivo
You Lv, Tao Ye, Hui-Peng Wang, Jia-Ying Zhao, Wen-Jie Chen, Xin Wang, Chen-Xia Shen, Yi-Bin Wu, Yuan-Kun Cai
You Lv, Tao Ye, Hui-Peng Wang, Jia-Ying Zhao, Wen-Jie Chen, Xin Wang, Chen-Xia Shen, Yi-Bin Wu, Yuan-Kun Cai, Department of General Surgery, The 5th People’s Hospital of Shanghai, Fudan University, Shanghai 200240, China
Author contributions: Lv Y, Ye T, Wang HP, Zhao JY, Wang X and Cai YK designed the research; Lv Y, Chen WJ and Wu YB performed the research; Lv Y and Zhao JY contributed new reagents or analytic tools; Lv Y, Wang X and Shen CX analyzed the data; Lv Y and Wang HP wrote the paper.
Supported by the Scientific Research Project of Shanghai Health and Family Planning, and the Commission and the 5th People’s Hospital of Shanghai, Fudan University under Grant No. 201440505.
Institutional review board statement: The study was reviewed and approved by the 1990 Animal Experimental Ethics Committee of East China Normal University Institutional Review Board.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Animal Care and Use Committee of the Animal Center of the Institute of Biomedical Laboratory of the East China Normal University (IACUC Protocol No. M20150503).
Conflict-of-interest statement: To the best of our knowledge, no conflict of interest exists.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at 18918168583@163.com. Participants gave informed consent for data sharing.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Yuan-Kun Cai, MD, Associate Professor, Chief Surgeon of General Surgery, Department of General Surgery, The 5th People’s Hospital of Shanghai, Fudan University, 801 Heqing Road, Shanghai 200240, China. 18918168583@163.com
Telephone: +86-21-64307611 Fax: +86-21-64307611
Received: September 11, 2016
Peer-review started: September 12, 2016
First decision: November 9, 2016
Revised: November 19, 2016
Accepted: December 8, 2016
Article in press: December 8, 2016
Published online: January 28, 2017
Core Tip

Core tip:Bacteroides fragilis enterotoxin-2 (BFT-2) has been considered to promote the development of colorectal cancer (CRC). In this study, we obtained the biologically active recombinant BFT-2 in vitro and found that lower-dose of biologically active BFT-2 could inhibit colorectal tumor formation via the route of intra-gastric administration in a mice model of CRC, which manifested to inhibit cell proliferation and promoted apoptosis. The specific mechanism is still unknown but the findings provide some insights into prevention and treatment of CRC as an intestinal mucosal vaccine.