Published online Jan 28, 2017. doi: 10.3748/wjg.v23.i4.563
Peer-review started: August 31, 2016
First decision: September 30, 2016
Revised: October 8, 2016
Accepted: November 12, 2016
Article in press: November 13, 2016
Published online: January 28, 2017
Core tip: Chronic atrophic autoimmune gastritis is an autoimmune disease characterized by progressive parietal cells destruction leading to hypochlorhydria and intrinsic factor deficiency. These alterations may result in vitamin B12 deficiency and iron malabsorption. A possible role of chronic atrophic autoimmune gastritis in the development of several nutritional deficiencies (e.g., calcium, vitamin D, vitamin C) has been reported. However, the prevalence and clinical impact of these deficiencies has not been elucidated. The present paper aims at investigating the relevance, frequency and clinical presentation of nutritional deficiencies in chronic atrophic gastritis to enable clinicians to promptly identify and correct any possible nutritional impairment.