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Cavalcoli F, Zilli A, Conte D, Massironi S. Micronutrient deficiencies in patients with chronic atrophic autoimmune gastritis: A review. World J Gastroenterol 2017; 23(4): 563-572 [PMID: 28216963 DOI: 10.3748/wjg.v23.i4.563]
World J Gastroenterol. Jan 28, 2017; 23(4): 563-572 Published online Jan 28, 2017. doi: 10.3748/wjg.v23.i4.563
Micronutrient deficiencies in patients with chronic atrophic autoimmune gastritis: A review
Federica Cavalcoli, Alessandra Zilli, Dario Conte, Sara Massironi
Federica Cavalcoli, Alessandra Zilli, Dario Conte, Sara Massironi, Gastroenterology and Endoscopy Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy
Federica Cavalcoli, Alessandra Zilli, Dario Conte, Postgraduate School of Gastroenterology, Department of Pathophysiology and Transplantation, Università degli Studi di Milano, 20122 Milan, Italy
Author contributions: Cavalcoli F and Massironi S planned the work; Zilli A performed the literature search; Cavalcoli F and Zilli A wrote the first draft of the manuscript; Cavalcoli F, Zilli A and Massironi S edited the subsequent versions of the manuscript; Conte D critically revised the manuscript for relevant intellectual content; finally, all authors read and approved the final manuscript.
Conflict-of-interest statement: No conflict of interests (including but not limited to commercial, personal, political, intellectual, or religious interests) to declare.
Correspondence to: Federica Cavalcoli, MD, Gastroenterology and Endoscopy Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Via F. Sforza 35, 20122 Milan, Italy. cavalcoli.federica@gmail.com
Telephone: +39-2-55033445 Fax: +39-2-55033644
Received: August 27, 2016 Peer-review started: August 31, 2016 First decision: September 30, 2016 Revised: October 8, 2016 Accepted: November 12, 2016 Article in press: November 13, 2016 Published online: January 28, 2017 Processing time: 144 Days and 18.2 Hours
Core Tip
Core tip: Chronic atrophic autoimmune gastritis is an autoimmune disease characterized by progressive parietal cells destruction leading to hypochlorhydria and intrinsic factor deficiency. These alterations may result in vitamin B12 deficiency and iron malabsorption. A possible role of chronic atrophic autoimmune gastritis in the development of several nutritional deficiencies (e.g., calcium, vitamin D, vitamin C) has been reported. However, the prevalence and clinical impact of these deficiencies has not been elucidated. The present paper aims at investigating the relevance, frequency and clinical presentation of nutritional deficiencies in chronic atrophic gastritis to enable clinicians to promptly identify and correct any possible nutritional impairment.
