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World J Gastroenterol. Jan 28, 2017; 23(4): 563-572
Published online Jan 28, 2017. doi: 10.3748/wjg.v23.i4.563
Micronutrient deficiencies in patients with chronic atrophic autoimmune gastritis: A review
Federica Cavalcoli, Alessandra Zilli, Dario Conte, Sara Massironi
Federica Cavalcoli, Alessandra Zilli, Dario Conte, Sara Massironi, Gastroenterology and Endoscopy Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy
Federica Cavalcoli, Alessandra Zilli, Dario Conte, Postgraduate School of Gastroenterology, Department of Pathophysiology and Transplantation, Università degli Studi di Milano, 20122 Milan, Italy
Author contributions: Cavalcoli F and Massironi S planned the work; Zilli A performed the literature search; Cavalcoli F and Zilli A wrote the first draft of the manuscript; Cavalcoli F, Zilli A and Massironi S edited the subsequent versions of the manuscript; Conte D critically revised the manuscript for relevant intellectual content; finally, all authors read and approved the final manuscript.
Conflict-of-interest statement: No conflict of interests (including but not limited to commercial, personal, political, intellectual, or religious interests) to declare.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Federica Cavalcoli, MD, Gastroenterology and Endoscopy Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Via F. Sforza 35, 20122 Milan, Italy. cavalcoli.federica@gmail.com
Telephone: +39-2-55033445 Fax: +39-2-55033644
Received: August 27, 2016
Peer-review started: August 31, 2016
First decision: September 30, 2016
Revised: October 8, 2016
Accepted: November 12, 2016
Article in press: November 13, 2016
Published online: January 28, 2017
Core Tip

Core tip: Chronic atrophic autoimmune gastritis is an autoimmune disease characterized by progressive parietal cells destruction leading to hypochlorhydria and intrinsic factor deficiency. These alterations may result in vitamin B12 deficiency and iron malabsorption. A possible role of chronic atrophic autoimmune gastritis in the development of several nutritional deficiencies (e.g., calcium, vitamin D, vitamin C) has been reported. However, the prevalence and clinical impact of these deficiencies has not been elucidated. The present paper aims at investigating the relevance, frequency and clinical presentation of nutritional deficiencies in chronic atrophic gastritis to enable clinicians to promptly identify and correct any possible nutritional impairment.