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©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 28, 2017; 23(36): 6685-6693
Published online Sep 28, 2017. doi: 10.3748/wjg.v23.i36.6685
Published online Sep 28, 2017. doi: 10.3748/wjg.v23.i36.6685
Prognostic value of lymphovascular invasion in Bismuth-Corlette type IV hilar cholangiocarcinoma
Bei Li, Xian-Ze Xiong, Yong Zhou, Si-Jia Wu, Zhen You, Jiong Lu, Nan-Sheng Cheng, Department of Biliary Surgery, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China
Author contributions: Li B analyzed the data and wrote the manuscript; Xiong XZ and Zhou Y collected all the human materials; Wu SJ, You Z and Lu J helped with data analysis; Cheng NS designed, organized, and supervised the writing of the manuscript; all authors approved the final manuscript as submitted.
Supported by Science and Technology Support Project of Sichuan Province , No. 2015SZ0070 and No. 2014FZ0049 .
Institutional review board statement: The study was reviewed and approved by the West China Hospital of Sichuan University Institutional Review Board.
Conflict-of-interest statement: We have no conflicts of interest regarding the current paper.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Nan-Sheng Cheng, MD, PhD, Department of Biliary Surgery, West China Hospital of Sichuan University, No. 37, Guoxue Alley, Chengdu 610041, Sichuan Province, China. nanshengcheng@yeah.net
Telephone: +86-28-85422465 Fax: +86-28-85422465
Received: June 18, 2017
Peer-review started: June 21, 2017
First decision: July 13, 2017
Revised: July 28, 2017
Accepted: August 25, 2017
Article in press: August 25, 2017
Published online: September 28, 2017
Peer-review started: June 21, 2017
First decision: July 13, 2017
Revised: July 28, 2017
Accepted: August 25, 2017
Article in press: August 25, 2017
Published online: September 28, 2017
Core Tip
Core tip: Previous studies have reported that lymphovascular invasion (LVI) provokes an adverse impact on the long-term survival of several malignances, including breast, gastric, and esophageal carcinoma, among many others. However, the correlation between LVI and hilar cholangiocarcinoma remains unclear. In our study, LVI was found to be an independent risk factor for overall survival and disease-free survival in Bismuth-Corlette type IV hilar cholangiocarcinoma patients. To our knowledge, this report indicates for the first time that LVI is an adverse predictor of long-term survival in the setting of type IV hilar cholangiocarcinoma.