Basic Study
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 7, 2017; 23(33): 6100-6110
Published online Sep 7, 2017. doi: 10.3748/wjg.v23.i33.6100
HOX transcript antisense intergenic RNA represses E-cadherin expression by binding to EZH2 in gastric cancer
Wen-Ming Chen, Wei-Dong Chen, Xue-Mei Jiang, Xue-Feng Jia, Hong-Mei Wang, Qiu-Jie Zhang, Yong-Qian Shu, Hai-Bo Zhao
Wen-Ming Chen, Wei-Dong Chen, Xue-Feng Jia, Qiu-Jie Zhang, Hai-Bo Zhao, Department of Oncology, Jining NO.1 People’s Hospital, Jining 272011, Shandong Province, China
Xue-Mei Jiang, Traditional Chinese Medicine Hospital of Jining City, Jining 272011, Shandong Province, China
Hong-Mei Wang, The Special Hospital Serving the Municipal Officials of Jining City, Jining 272011, Shandong Province, China
Yong-Qian Shu, Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing 210029, Jiangsu Province, China
Author contributions: Chen WM and Chen WD contributed equally to this article; Shu YQ and Zhao HB conceived and designed the study; Chen WM, Chen WD, Zhao HB, Jiang XM and Wang HM performed the research; Zhang QJ and Jia XF analyzed and interpreted the data; Chen WM and Zhao HB drafted the manuscript.
Supported by the Shandong Provincial Natural Science Foundation of China, No. ZR2016HQ08; Shandong Province Medical Science and Technology Development Projects of China, No. 2016WS0151; and the Jining Municipal Project on Science and Technology Development of China, No. 2013jnwk58.
Institutional review board statement: This study was reviewed and approved by the Jining NO.1 People’s Hospital Institutional Review Board and Nanjing Medical University Institutional Review Board.
Conflict-of-interest statement: The authors declare that no conflict of interest exists in relation to this study.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Hai-Bo Zhao, Associate Chief Physician, Department of Oncology, Jining NO.1 People’s Hospital, NO.6, Jiankang Road, Jining 272011, Shandong Province, China. zhbys@sina.com
Telephone: +86-537-6051446 Fax: +86-537-2256374
Received: December 24, 2016
Peer-review started: December 29, 2016
First decision: March 18, 2017
Revised: April 13, 2017
Accepted: July 22, 2017
Article in press: July 24, 2017
Published online: September 7, 2017
Core Tip

Core tip: In this study, we found that HOX transcript antisense intergenic RNA (HOTAIR) expression was up-regulated in gastric cancer (GC) tissues. High expression of HOTAIR was associated with clinicopathological characteristics and poor prognosis in GC patients. Additional experiments revealed that HOTAIR knockdown significantly inhibited the invasion and migration of GC cells. We also tested whether HOTAIR recruited EZH2 to promote tumor cell migration and invasion by repressing E-cadherin in GC. The findings from our study will help clarify the role of HOTAIR in GC progression and its potential as a therapeutic target.